This PhD thesis examines the role of intermediary organizations in solving system problems in regional innovation systems in Spain. It creates typologies that group Spanish regions based on the presence or absence of system problems like lack of management capabilities, and intermediary categories that address these problems. Statistical analysis shows active intermediary components are associated with more integrated regional innovation systems that have fewer system problems, while inactive components correlate with less integrated systems facing more challenges. The thesis advances conceptual and methodological understandings of how intermediaries influence regional economic competitiveness.