When developing web applications with PHP and MySQL, errors can occur in the HTML, PHP code, SQL queries, or MySQL. To debug issues, first determine the problem area. Common PHP errors include logical errors, runtime errors, and syntactical errors. SQL errors are usually due to incorrect syntax. Debugging techniques include checking that the correct page is being run, saving changes, using the URL to run PHP pages, displaying PHP errors, logging errors to files, and commenting out lines of code.