This document presents a framework for transforming organizations into "living businesses" through human-centered design. It discusses balancing four vital signs - personality, craft, instinct, and relationships. It also recognizes five biases that can influence organizations - relationships, craft, instinct, power, and behavior. The document then outlines eight "doors" or starting points for transformation: spark change, split transformation tracks, reflect on customer perspectives, illustrate the vision, sprint at digital pace, partner openly, nurture an engaged culture, and infect the organization with new approaches. It argues this process is not linear and organizations can start through any door, repeating and spreading changes infectiously. The goal is to solve problems through human-centric problem solving and design to help