South Africa has made progress in health since 1994 but still faces challenges. Life expectancy has increased from 49 years to 60 but health inequalities remain large between provinces. The quadruple burden of disease includes communicable diseases, chronic diseases, injuries, and HIV/AIDS. The National Health Insurance and re-engineering of primary health care aim to improve access and quality but face challenges in implementation. Continued efforts are needed to address social determinants of health and implement priority initiatives to reduce health inequities.