The document compares REST and gRPC approaches to building APIs. It notes that while REST uses JSON over HTTP, gRPC uses protocol buffers over HTTP/2, allowing for benefits like binary encoding, multiplexing, and simpler parsing. An example shows a character request is 205 characters in JSON but only 44 bytes in protocol buffers. gRPC is also said to allow lower latency, better CPU utilization, and server push capabilities compared to REST for real-time use cases.