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Aarti Sareen
                     MSPT Honours I
                       Roll No. 8


HOSPITAL ACQUIRED INFECTIONS
Hospital acquired infection is also
  called Nosocomial infection or
  Healthcare-associated infections.
"nosus" = disease
 "komeion" = to take care of
 Nosocomial infections can be defined
   as infection acquired by the person
   in the hospital, manifestation of
   which may occur during
   hospitalization or after discharge
   from hospital. The person may be a
   patient, members of the hospital
   staff and/ or visitors.
Hospital acquired infections
EPIDEMIOLOGICAL INTERACTION
                               HOST FACTORS
                               Suppresed immune system due to Age, Poor
                               nutritional status, severity of underlying
                               disease, complicated diagnostic & therapeutic
                               procedure,therapeutic,
              NCI

                                  THE ENVIRNOMNET
                                  Everything that surrounds the patient
THE AGENT
                                  in the hospital is his environment.
Varieties of organisms
                                  Other patients
Institutional and human           Hospital staff and visitors
                                  Eatables
Reservoirs & their virulence      Dust and other contaminated articles
SOURCE OF INFECTION
                                Exogenous/indirect
Endogenous/direct:       Caused by organisms acquiring by
                         exposure to hospital personnel, medical
Caused by the            devices or hospital environment, cross-
                         infection from medical personnel
 organisms that are    • hospital environment- inanimate
                         objects
 present as part of       – air
 normal flora of the      – dust
                          – IV fluids & catheters
 patient                  – washbowls
                          – bedpans
                          – endoscopes
                          – ventilators & respiratory equipment
                          – water, disinfectants etc
EXOGENOUS INFECTION SITES
The Inanimate Environment Can Facilitate Transmission




       ~ Contaminated surfaces increase cross-transmission ~
Exogenours
Pathogens
Nosocomial Infections:
           Changing Microbiology


• Mid-1980’s             • Mid-1990’s
  – Enterobacteriaceae     – Decline in
                             Enterobacteriaceae
  – S. aureus
                           – Increase in gram-
  – P. aeruginosa
                             positive cocci
                           – Emergence of fungi
                           – Recognition of viruses
All microorganisms can cause
        nosocomial infections

Viruses
Bacteria
Fungi
Parasites
BACTERIA
Gram +ve
  Staphylococcus aureus
  Staphylococcus epidermidis
Gram -ve
  Enterobacteriaceae
  Pseudomonas aeruginosa
  Acinetobacter baumanni
  Mycobacterium tuberculosis
COMMON BACTERIAL AGENTS


                 Pseudomonas (9%)
                 aeruginosa
                 Enterococcus (10%)

                 Coag-neg staphylococcl
                              (11%)
                 E-coli
                              (12%)
                 Staphylococcus aureus
                             (13%)
                 Other
                          (45%)
Viruses
◦ Blood borne infections : HBV, HCV, HIV
◦ Others: rubella, varicella, SARS



Fungi
◦ Candida
◦ Aspergillus
TYPES OF INFECTIONS

– Urinary tract infections (UTI)
– Surgical wound infections (SWI)
– Lower respiratory infections
– Traumatic wounds and burns infections
– Primary bacteraemia
– Gastrointestinal tract
– Central nervous system
Major Types of Nosocomial Infections

35

30

25
                                         UTI
20                                       Pneumonia
15                                       SWI
                                         Bloodstream
10                                       Other

 5

 0                                   Richards, MJ. 1999.
        Overall          ICU         Crit Care Med 27; 887.
Mode of trasmission

Contact/hand borne (most common)

Aerial route or air borne

Oral route

Parenteral route

Vector borne
1. Contact (most common)

     Direct (physical contact)
   – Hands & clothing
   – Droplet contact followed
      by autoinoculation
   – Clinical equipment

Indirect via contaminated articles
   –        Bedpans,
   – bowls, jugs,
   – Instruments like needles,
   – dressings,
   – contaminated gloves,etc.
2. Airborne Transmission
  – Droplet respiratory secretions on surfaces
  – Inhalation of infectious particles
  e.g. (TB, Varicella)
3. Oral route
4. Parenteral route
5. Vector borne: through mosquitoes, flies,
   rats
Pathogens transmission
The hands are the most important
    vehicle of transmission of
               HCAI
Why
 Don’t Staff Wash
   their Hands
(Compliance estimated at less than 50%)
Why Not?
•   Skin irritation
•   Inaccessible hand washing facilities
•   Wearing gloves
•   Too busy
•   Lack of appropriate staff
•   Being a physician
    (“Improving Compliance with Hand Hygiene in Hospitals” Didier Pittet. Infection
    Control and Hospital Epidemiology. Vol. 21 No. 6 Page 381)
Hand Hygiene Techniques
1. Alcohol hand rub

2. Routine hand wash 10-15 seconds

3. Aseptic procedures 1 minute

4. Surgical wash 3-5 minutes
Routine Hand Wash




Repeat procedures until hands are clean
Areas Most Frequently Missed




             HAHS © 1999
Hand Care
• Nails
• Rings
• Hand creams
• Cuts & abrasions
• “Chapping”
• Skin Problems
Hand hygiene is the
simplest, most effective
measure for preventing
   hospital-acquired
      infections.
Surveillance
Why surveillance?
• NCI cause of morbidity and mortality
• One third may be preventable
• Surveillance = key factor
  – an infection control measure
  – overview of the burden and distribution of NCI
  – allocate preventive resources
• Surveillance is cost-efficient!!
Objectives
•   Reducing infection rates
•   Establishing endemic baseline rates
•   Identifying outbreaks
•   Identifying risk factors
•   Persuading medical personnel
•   Evaluate control measures
•   Satisfying regulators
•   Document quality of care
•   Compare hospitals’ NCI rates
The surveillance loop
Health care                     Surveillance centre
system


                Reporting

Event                           Data




                                                      interpretation
                                                        Analysis,
Action                          Information
                  Feedback,
              recommendations
Considerations when creating a
       surveillance system
• Goal of the surveillance system (why)
• Engage the stakeholders (who)
• Surveillance method (what, how, when)
  – definition
  – what to collect
  – how to collect (operation of system)
• Available resources
Who

• All hospitals?

• All departments?

• All specialties?

• Other health institutions?
Stakeholders

                                           Central
                                            adm.             Local
                           …..
                                                             adm.
          Public
         Health                                                                 ICP
        instituteI


                                                                                       It-
Directorat
                                    Surveillance of                                   dep.
                                 surgical site infections

Ministry                                                                          Surgical
Of health                                                                          wards

                 Service                                             Surgical
                  dep.                                               ward. 2
                                   Lab            Patients
Hospital acquired infections
Control of NCI
Goals for infection control and hospital
                 epidemiology
There are three principal goals for hospital infection
   control and prevention programs:
1. Protect the patients
2. Protect the health care workers, visitors, and others
   in the healthcare environment.
3. Accomplish the previous two goals in a cost
   effective and cost efficient manner, whenever
   possible.
.
To control the
nosocomial
infection we need
to consider the
chain of infection
and the
transmission of an
infectious agent
Prevention & control of nosocomial
                  infections
–   observance of aseptic technique
–   frequent hand washing especially between
    patients
–   careful handling, cleaning, and disinfection of
    fomites
–   where possible use of single-use disposable
    items
–   patient isolation
–   avoidance where possible of medical procedures
    that can lead with high probability to nosocomial
    infection (urinary catheter)
Prevention & control of nosocomial infections
                  (cont.)
 – Various institutional methods such as air filtration
   within the hospital
 – Appropriate isolation precautions to protect
   patients, visitors, and HCWs.
 – Surveillance for common infections, monitoring of
   high risk patients, and hospital area to identify
   outbreaks, document incidence and prevalence
   rate of specific infections and set goal for
   improvement.
Uttermost care should be taken in following
  services:
• House keeping
• Dietary services
• Linen and laundry
• Central sterile supply department
• Nursing care
• Waste disposal
• Antibiotic policy
• Hygiene and sanitation
Isolation & barrier precautions




Decontamination of equipment




Prudent use of antibiotics




Hand washing




Decontamination of environment
                                  The 5 pillars of infection control
Infection Control Committee
Infection control Committee (ICC):


The hospital ICC is charged with the
 responsibility for the planning, evaluation of
 evidenced-based            practice        and
 implementation, prioritization and resource
 allocation of all matters relating to infection
 control.
Infection Control Team

Infection Control Doctor (ICD)   Infection Control Nurse (ICN)
Role of infection control teams

 • Education and training
 • Development and dissemination of
   infection control policy
 • Monitoring and audit of hygiene
 • Clinical audit

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Hospital acquired infections

  • 1. Aarti Sareen MSPT Honours I Roll No. 8 HOSPITAL ACQUIRED INFECTIONS
  • 2. Hospital acquired infection is also called Nosocomial infection or Healthcare-associated infections. "nosus" = disease "komeion" = to take care of Nosocomial infections can be defined as infection acquired by the person in the hospital, manifestation of which may occur during hospitalization or after discharge from hospital. The person may be a patient, members of the hospital staff and/ or visitors.
  • 4. EPIDEMIOLOGICAL INTERACTION HOST FACTORS Suppresed immune system due to Age, Poor nutritional status, severity of underlying disease, complicated diagnostic & therapeutic procedure,therapeutic, NCI THE ENVIRNOMNET Everything that surrounds the patient THE AGENT in the hospital is his environment. Varieties of organisms Other patients Institutional and human Hospital staff and visitors Eatables Reservoirs & their virulence Dust and other contaminated articles
  • 5. SOURCE OF INFECTION Exogenous/indirect Endogenous/direct: Caused by organisms acquiring by exposure to hospital personnel, medical Caused by the devices or hospital environment, cross- infection from medical personnel organisms that are • hospital environment- inanimate objects present as part of – air normal flora of the – dust – IV fluids & catheters patient – washbowls – bedpans – endoscopes – ventilators & respiratory equipment – water, disinfectants etc
  • 7. The Inanimate Environment Can Facilitate Transmission ~ Contaminated surfaces increase cross-transmission ~
  • 9. Nosocomial Infections: Changing Microbiology • Mid-1980’s • Mid-1990’s – Enterobacteriaceae – Decline in Enterobacteriaceae – S. aureus – Increase in gram- – P. aeruginosa positive cocci – Emergence of fungi – Recognition of viruses
  • 10. All microorganisms can cause nosocomial infections Viruses Bacteria Fungi Parasites
  • 11. BACTERIA Gram +ve Staphylococcus aureus Staphylococcus epidermidis Gram -ve Enterobacteriaceae Pseudomonas aeruginosa Acinetobacter baumanni Mycobacterium tuberculosis
  • 12. COMMON BACTERIAL AGENTS Pseudomonas (9%) aeruginosa Enterococcus (10%) Coag-neg staphylococcl (11%) E-coli (12%) Staphylococcus aureus (13%) Other (45%)
  • 13. Viruses ◦ Blood borne infections : HBV, HCV, HIV ◦ Others: rubella, varicella, SARS Fungi ◦ Candida ◦ Aspergillus
  • 14. TYPES OF INFECTIONS – Urinary tract infections (UTI) – Surgical wound infections (SWI) – Lower respiratory infections – Traumatic wounds and burns infections – Primary bacteraemia – Gastrointestinal tract – Central nervous system
  • 15. Major Types of Nosocomial Infections 35 30 25 UTI 20 Pneumonia 15 SWI Bloodstream 10 Other 5 0 Richards, MJ. 1999. Overall ICU Crit Care Med 27; 887.
  • 16. Mode of trasmission Contact/hand borne (most common) Aerial route or air borne Oral route Parenteral route Vector borne
  • 17. 1. Contact (most common) Direct (physical contact) – Hands & clothing – Droplet contact followed by autoinoculation – Clinical equipment Indirect via contaminated articles – Bedpans, – bowls, jugs, – Instruments like needles, – dressings, – contaminated gloves,etc.
  • 18. 2. Airborne Transmission – Droplet respiratory secretions on surfaces – Inhalation of infectious particles e.g. (TB, Varicella) 3. Oral route 4. Parenteral route 5. Vector borne: through mosquitoes, flies, rats
  • 20. The hands are the most important vehicle of transmission of HCAI
  • 21. Why Don’t Staff Wash their Hands (Compliance estimated at less than 50%)
  • 22. Why Not? • Skin irritation • Inaccessible hand washing facilities • Wearing gloves • Too busy • Lack of appropriate staff • Being a physician (“Improving Compliance with Hand Hygiene in Hospitals” Didier Pittet. Infection Control and Hospital Epidemiology. Vol. 21 No. 6 Page 381)
  • 23. Hand Hygiene Techniques 1. Alcohol hand rub 2. Routine hand wash 10-15 seconds 3. Aseptic procedures 1 minute 4. Surgical wash 3-5 minutes
  • 24. Routine Hand Wash Repeat procedures until hands are clean
  • 25. Areas Most Frequently Missed HAHS © 1999
  • 26. Hand Care • Nails • Rings • Hand creams • Cuts & abrasions • “Chapping” • Skin Problems
  • 27. Hand hygiene is the simplest, most effective measure for preventing hospital-acquired infections.
  • 29. Why surveillance? • NCI cause of morbidity and mortality • One third may be preventable • Surveillance = key factor – an infection control measure – overview of the burden and distribution of NCI – allocate preventive resources • Surveillance is cost-efficient!!
  • 30. Objectives • Reducing infection rates • Establishing endemic baseline rates • Identifying outbreaks • Identifying risk factors • Persuading medical personnel • Evaluate control measures • Satisfying regulators • Document quality of care • Compare hospitals’ NCI rates
  • 31. The surveillance loop Health care Surveillance centre system Reporting Event Data interpretation Analysis, Action Information Feedback, recommendations
  • 32. Considerations when creating a surveillance system • Goal of the surveillance system (why) • Engage the stakeholders (who) • Surveillance method (what, how, when) – definition – what to collect – how to collect (operation of system) • Available resources
  • 33. Who • All hospitals? • All departments? • All specialties? • Other health institutions?
  • 34. Stakeholders Central adm. Local ….. adm. Public Health ICP instituteI It- Directorat Surveillance of dep. surgical site infections Ministry Surgical Of health wards Service Surgical dep. ward. 2 Lab Patients
  • 37. Goals for infection control and hospital epidemiology There are three principal goals for hospital infection control and prevention programs: 1. Protect the patients 2. Protect the health care workers, visitors, and others in the healthcare environment. 3. Accomplish the previous two goals in a cost effective and cost efficient manner, whenever possible. .
  • 38. To control the nosocomial infection we need to consider the chain of infection and the transmission of an infectious agent
  • 39. Prevention & control of nosocomial infections – observance of aseptic technique – frequent hand washing especially between patients – careful handling, cleaning, and disinfection of fomites – where possible use of single-use disposable items – patient isolation – avoidance where possible of medical procedures that can lead with high probability to nosocomial infection (urinary catheter)
  • 40. Prevention & control of nosocomial infections (cont.) – Various institutional methods such as air filtration within the hospital – Appropriate isolation precautions to protect patients, visitors, and HCWs. – Surveillance for common infections, monitoring of high risk patients, and hospital area to identify outbreaks, document incidence and prevalence rate of specific infections and set goal for improvement.
  • 41. Uttermost care should be taken in following services: • House keeping • Dietary services • Linen and laundry • Central sterile supply department • Nursing care • Waste disposal • Antibiotic policy • Hygiene and sanitation
  • 42. Isolation & barrier precautions Decontamination of equipment Prudent use of antibiotics Hand washing Decontamination of environment The 5 pillars of infection control
  • 44. Infection control Committee (ICC): The hospital ICC is charged with the responsibility for the planning, evaluation of evidenced-based practice and implementation, prioritization and resource allocation of all matters relating to infection control.
  • 45. Infection Control Team Infection Control Doctor (ICD) Infection Control Nurse (ICN)
  • 46. Role of infection control teams • Education and training • Development and dissemination of infection control policy • Monitoring and audit of hygiene • Clinical audit