Human blood brain barrier
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The document discusses a human blood-brain barrier (BBB) model characterized with primary human cells and engineered hydrogels to mimic the in vivo extracellular matrix. It highlights the importance of stiffness, customizable features, and high-throughput screening capabilities. Additionally, it details the optimization of protocols for assessing drug permeability and toxic assays in the BBB model.
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Human blood brain barrier
- 1. Human Blood Brain Barrier Characterized, Tested and Discovery Ready
- 2. Features • Populated with 21-CFR primary human cells • Engineered hydrogels to mimic in vivo ECM • Stiffness matters • Customizable • For high throughput screening 96 wells • Cell types to order
- 3. TEER (trans endothelial electrical resistance) in BBB model • TEER in BBB model reaches more than 150 Ω×cm2 , and maintains a plateau up to 7 days. • Key to validating tight gap junctions
- 4. Permeability Assay • Protocol optimized for permeability assays • Drug discovery and toxic assays
- 5. Apparent Permeability Coefficients (Papp)
- 7. Customers