Django is a high-level Python web framework that encourages rapid development and clean, pragmatic design. It makes building better web apps faster with less code. Django uses models, templates, and views following an MTV pattern instead of MVC. To build a project, you start a project with startproject and then add apps with startapp. Models define the database structure, views handle requests and responses, and templates display content. The database is created and synced using manage.py commands. URLs map requests to views and the development server is run with runserver. The admin interface provides administration tools out of the box.