This document discusses vision-based sign language translation using MATLAB. It describes a system that uses a camera to capture images of hand gestures representing letters or words in sign language. MATLAB is used to analyze the images, recognize the gestures, and translate them into spoken words that are output through a speaker. The system aims to help deaf, mute, and blind individuals communicate more easily. Several image processing and machine learning techniques for hand segmentation, feature extraction, and classification are reviewed from previous studies. The results suggest this type of system could accurately translate sign language in real-time.