This document contains lecture notes on integration by substitution from a Calculus I class. It introduces the technique of substitution for both indefinite and definite integrals. For indefinite integrals, the substitution rule is presented, along with examples of using substitutions to evaluate integrals involving polynomials, trigonometric, exponential, and other functions. For definite integrals, the substitution rule is extended and examples are worked through both with and without first finding the indefinite integral. The document emphasizes that substitution often simplifies integrals and makes them easier to evaluate.