Load and store instructions first generate an effective address, then perform address translation before accessing the data cache for load or store operations. For loads, the cache is read to return data, while stores write data to the cache. Stores are held in the store buffer until retirement to maintain load-store ordering. Loads can bypass and forward from earlier stores in the store buffer to improve performance. Memory dependencies between loads and stores are difficult to handle due to dynamic addresses and long memory latency. Speculative load disambiguation predicts dependencies to allow out-of-order execution when aliases are rare.