The document outlines the establishment and objectives of the UNESCO-supported UNESCOD Center dedicated to Mediterranean biosphere reserves, which aims to enhance biodiversity conservation and promote sustainable development through research and collaboration. Additionally, it discusses a doctoral study that investigates the impacts of global change on the ecological quality of Mediterranean river basins, highlighting land use changes and their effects on water quality. The findings suggest the need for interdisciplinary tools and long-term monitoring programs to improve the ecological assessment and management of river systems.