1. Medical Physics Study Design
Professor Wu
SCI publishing workshop
in Department of Physics
Universitas Ahmad Dahlan
Dept.
Advisor
Line & WeChat
Rev 1.01, 01.08.2024
Rev 2.01, 01.15.2024
2. Obesity and its accompanying health
problems almost ended my life
Two major changes in life:
Active weight loss (lost 26 Kg
in a year)
• kept the weight off
• an effective and safe health
and wellness method
Changed research topic
telecommunications→ medical
engineering
Published over 60 SCI
medical papers
Developing preventive medicine
instruments
Encourage students to publish
SCI papers
3. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
4. Importance of Interdisciplinary Studies
The application of physics to medicine
‒ Medical Physics
Using physics concepts and procedures in the
prevention, diagnosis, and treatment of disease
Examples: Ultrasound, Magnetic Resonance,
Nuclear Medicine, X-rays, Radiation Therapy,
….
Special Application of entropy in Harvard
University (i.e., Multiscale Entropy)
Costa M, Goldberger AL, Peng CK. Multiscale entropy
analysis of biological signals. Phys Rev E Stat Nonlin Soft
Matter Phys. 2005, 71, 021906.
doi:10.1103/PhysRevE.71.021906
5. Quiz on physiologic dynamics by Dr. Peng CK
Heart Failure Heart Failure
Normal Atrial Fibrillation
• Loss of dynamical fluctuations is bad
• Not all dynamical fluctuations are good
Heart
Rate
(bpm)
Heart
Rate
(bpm)
Heart
Rate
(bpm)
Heart
Rate
(bpm)
Time (min) Time (min)
6. Physics & Medical Science Connection
The impact of supplementary hands-on practice
on learning in introductory computer science
course for freshmen (SCI, IF=12, 2022, Q1)
Computers & Education 2014, vol.70, pp.1-8.
8. Pressure pulse waves provided an essential
diagnostic technique
in Traditional Chinese Medicine
9. (D)
X-rays
(A) (B)
(C)
Urodynamic equipment:
(A) It is a double-lumen catheter:
infused with contrast agent
physiological saline, measuring
intravesical pressure.(B) Surface
electrode patch, measuring
surface electromyography (EMG)
of the external urethral sphincter.
Physics Principles Applied to Medical
Research in
‒ Primary Bladder Neck Obstruction
11. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
12. Physics students can bridge the gap
between their current knowledge and
medical study
1. Explore interdisciplinary courses
2. Attend seminars
3. Collaborate with students from the
medical field
4. Collaborate with professor working in
the medical field
13. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
14. Various paths available for physics
students to enter the medical field
1. Pursuing medical physics
2. Pursuing biomedical engineering
3. Collaborate with doctors
4. Transitioning to medical school
15. The importance of gaining hands-on
experience through
1. Internships
2. Research projects
3. Volunteering in healthcare settings
Ethics approval and consent to participate
This study was approved by the Research Ethics
Committee of Taichung Tzu Chi Hospital, Buddhist Tzu Chi
Medical Foundation and registered with the number of ICF:
06/08/2017, REC No.: REC106-22. Written informed
consent has been obtained from the patients to publish this
study.
16. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
17. The significance of research in medical physics
Pulse wave velocity (PWV) is correlated with
cardiovascular risk.
Current used applanation tonometry (PWV-AT)
A new method: measuring the arterial PWV by
simultaneously recording the digital volume
pulse through the finger and the toe
Reproducibility of PWV-DVP
Correlation Between PWV-DVP and PWV-AT
Effects of Risk Factors
Association of Risk Factors
With Increased Pulse Wave
Velocity Detected by a Novel
Method Using Dual-Channel
Photoplethysmography
AJH 2005; 18:1118–1122
19. Medical Physics Study Process
Clinical Medicine Problem Discovery
(Innovative Ideas)➾Interdisciplinary Awesome
Data from Hospital Devices
Data from Self-developed Devices
Data Analysis Methods
1. EMD, 2. MSE, 3. PEI
Medical Statistics
Manuscript Writing
Publication Process
23. Medical Statistics with SPSS
• Why Medical Statistics ①
• Normality test & Coefficient of Variation
• Parameter estimation & Hypothesis test
• Bland–Altman plots / Correlation
• Analysis of Variance (ANOVA)②
• Multivariate linear regression
• Logistic regression prediction
• Survival analysis and Log-rank test
• Cox proportion hazard regression③
25. Medical Physics Study Design I
Reactive Hyperemia-Triggered Wrist Pulse Analysis for Early
Monitoring of Young Men with High Atherosclerotic Risk
Diagnostics 2021, 11, 1918. (SCI, IF=3.6, 2022, Q2)
26. Calculation of an Improved Stiffness Index Using Decomposed
Radial Pulse and Digital Volume Pulse Signals
J. Pers. Med. 12(11), 1768. (SCI, IF=3.5, 2022, Q2)
Medical Physics Study Design II
27. Medical Physics Study Design III
Skin Carotenoid Score as an Important Prognostic Factor for
Predicting Type 2 Diabetes Mellitus in Middle-Aged Subjects
Current Topics in Nutraceutical Research, 2023. (SCI)
28. Writing up and submitting an article to
a scientific journal
Before writing
Why bother to write up?
Ingredients of a good article
General structure of a scientific article:
“IMRaD”
How to choose a suitable journal for
your article
The submission process
Responses to reviewers
29. Before starting to write
What is the medical hypothesis for the
research question?
What are your research objectives?
What is the best method to achieve your
research objectives?
Do you have the necessary resources for
conducting the research methods?“
Which positive and negative controls will you
use?
More:
Required ethical approvals?
Statistical power → meaningful results?
Statistical power analysis?
30. Will your paper be accepted?
Originality (novelty)
Logics
Significance
Documentation of conclusions
Clarity of presentation
Extra “scores”:
Large sample numbers;
Much work performed;
Reliability of results
31. IMRaD
Title Page (Authors/Affiliations/Running title)
Abstract
Introduction
Methods
Results (Text/Tables/Figures & Figure Legends)
Discussion (without conclusions)
Conclusions
A. Acknowledgement (“Acknowlegment”)
B. Authors’ contributions / Funding
C. Ethics Approval and Consent to Participate
References
32. Recommended to write your manuscript in
the following order
1. Results (You can write these contents first
while conducting experiments and collecting
results.)
2. Materials and Methods
3. Conclusion (Summarize your unique results )
4. Introduction
5. Discussion
6. Title
7. Abstract
33. Choosing a target journal
Key considerations:
The topics the journal publishes (Clinical /
Engineering / Experimental / Case report
acceptable)
The journal’s target audience
The “impact” of your findings (Originality /
Significance / Reliability of results e.g.
sample size, exhaustive methods used for
verifying findings) → appropriate “Impact
factor”
Beware of scams!!!
Find a Elsevier journals:
34. Submitting a journal manuscript &
peer review
Know how to select a suitable journal
for your manuscript
The submission process
Understand how editors assess your
work
Outcomes of a submission
Know your options—including
transfers, revisions, and resubmission—
in case of rejection
How to respond to reviewers: Revising
& Responding
35. Revising & Responding
Point-by-point Don’t ignore ANY “minor” point
raised by the reviewer
Polite ALWAYS showing great respect for the
Reviewers’
Positive No argument / No rebuttal / No negative
feeling
Persuasive Be informative / Including
appropriate references / Adding data as far as
possible if rquested
36. Date Manuscript in Progress
01/
11/
2021－04/
11/
2021 Rejected by 1Big Data Research (Q1)
05/
26/
2021－07/
13/
2021 2
Biomed Research International submitted
07/
13/
2021－07/
17/
2021 “with editor” for 48 days → Withdraw
07/
17/
2021 Re-submitted to 3
Applied Sciences
07/
18/
2021 Pending review
07/
19/
2021 Under review /Reject
08/
07/
2021 Submitted to Journal: 4BSPC (Q2, IF = 3.880)
08/
09/
2021 Manuscript ID: BSPC-D-21-01618 with editor
08/
20/
2021 under review
09/
03/
2021 Required Reviews Completed
09/
05/
2021 Decision in Process
09/
07/
2021 First decision: Major Revision
? Prompt Revision
09/
10－09/
15/
2021 English editing
09/
16/
2021 First revised version resubmitted
09/
17/
2021 With Editor
09/
20/
2021 Revision Under Review
09/
26/
2021 Required Reviews Completed
09/
26/
2021 Decision in Process
09/
30/
2021 Accept
Submission Schedule
37. Biocybernetics and Biomedical Engineering
Impact Factor: 4.314 (2021) /6.4 (2022) 2.1⇧
06/
29/
2020 Diagnositics rejected
07/
05/
2020 Medicina rejected
07/
13/
2020 Scientific Reports rejected
07/
29/
2020 Electronics rejected
08/
22/
2020 Computational and Mathematical Methods in Medicine rejected
08/
25/
2020 ~12/
01/
2020 Biomed Tech rejected
12/
21/
2020 Manuscript ID: BBE-D-20-00640 submitted
12/
22/
2020 with editor
01/
08/
2021 under review
06/
11/
2021 Required Reviews Completed
06/
13/
2021 First decision: revise
06/
16/
2021 English editing
06/
17/
2021
First revised version resubmitted
BBE-D-20-00640R1
06/
17/
2021 under review
07/
20/
2021 Decision in Process
07/
21/
2021 Revise (only 1 minor comment left)
07/
27/
2021 English editing
07/
29/
2021
Revision Submitted to Journal
BBE-D-20-00640R2
07/
30/
2021 with editor
07/
31/
2021 Decision in Process
08/
01/
2021 Accept
38. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
39. Benefits of Choosing Medical Study
1. The potential career opportunities
and job satisfaction in medical
study
2. The impact on healthcare and
patient outcomes
3. The collaborative and diverse
nature of the medical field,
offering a dynamic and rewarding
career path
40. Contents
Why Medical Study for Physics Students
Bridging the Gap
How to Start Medical Study
Navigating Research in Medical Physics
Benefits of Choosing Medical Study
Conclusion
41. Conclusion
The advantages of combining physics
and medical study
To explore this exciting interdisciplinary
path
Make a meaningful impact on healthcare
Encourage students to publish SCI papers
42. Special Issue: Entropy Methods for Physiological
Signal Analysis
• Guest Editor: Prof. Dr. Hsien-Tsai Wu
• Deadline for submissions: 29 February 2024
• Website:
https://www.mdpi.com/journal/entropy/special_is
sues/I3186GJOKD
Editor's Notes
#3:Data vs. Statistical description Chapter1~2
Mean vs. Statistical inference Chapter3~5
Variables vs. Statistical regression Chapter6~9
