James Hetherington discusses the University of Nottingham's experiences with MySQL over time. They initially ran standalone MySQL databases across various systems before consolidating to centralized "database hosting" services using MySQL 5.0 in 2007. In 2012, they moved a key application to Moodle on MySQL. This worked well initially but had performance issues. Working with Oracle support improved the situation. They now use MySQL Enterprise editions with features like replication, monitoring, and clustering to power critical applications and services at scale. Moving forward, they aim to upgrade more systems to newer MySQL versions and explore additional MySQL and Oracle technologies and cloud platforms.