Network, Technology, and Data: Missing Pieces of the Puzzle for Clinical Trials Success
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The document outlines Health Catalyst's strategies and offerings aimed at improving the efficiency and success of clinical trials through data and technology. It highlights the challenges faced in patient recruitment and trial execution, while also presenting solutions such as the Health Catalyst Research Network and Touchstone Match to streamline patient identification and enrollment. Overall, it emphasizes the importance of high-quality data and connectivity in advancing clinical research and improving healthcare outcomes.
Network, Technology, and Data: Missing Pieces of the Puzzle for Clinical Trials Success
- 1. Network, Technology, and Data: Missing Pieces of the Puzzle for Clinical Trials Success Sadiqa Mahmood GM & SVP, Life Sciences Business Health Catalyst Raymond Sanchez, MD Chief Medical Officer Cerevel Therapeutics
- 2. © Health Catalyst. Confidential and proprietary. Poll Question: Which organization best describes where you work? a) Biopharma b) Hospital or Clinic – 10% c) Clinical Research Organization (CRO) – 5% d) Financial Institution – 10% e) Patient Advocacy Group f) Others – 75% 2
- 3. Health Catalyst Solutions: Health Catalyst Research Network (HCRN) and Touchstone Match Emmanuel Cocodia MBA VP. Product Strategy (Life Sciences)
- 4. © Health Catalyst. Confidential and proprietary. Poll Question: Which phases of clinical development cycle do you support in your current role? A. Phase 1 –12.5% B. Phase 2 – 18.8% C. Phase 3 – 31.3% D. Phase 4 – 12.5% E. Not Applicable – 62.5% 4
- 5. © Health Catalyst. Confidential and proprietary. Today discussion… • Health Catalyst . . Who we are? • Clinical Trials Conundrum • Health Catalyst Solutions • Summary
- 6. © Health Catalyst. Confidential and proprietary. Our mission is to be the catalyst for massive, measurable, data-informed healthcare improvement Our flywheel represents how we accomplish our mission
- 7. © Health Catalyst. Confidential and proprietary. We Exist to Make Healthcare Run Better "Using data and analytics, we have saved millions of dollars and improved our ability to deliver on our mission of enhancing the greater health of individuals, families, and communities.” Jonathan Shoemaker, SVP-CIO Allina Health $8.3M Revenue Increase From Improved Patient Scheduling $24M LOS Savings Across Health System $17.4M Cost Reduction From Supply Chain Optimization $5.4M Clinical Variation Cost Reduction in Sepsis $14M Revenue Increase From Improved Clinical Documentation $4.5M Reduction in Denials 7
- 8. © Health Catalyst. Confidential and proprietary. Select Health Catalyst Customers 8
- 9. ©2021 Health Catalyst Company Confidential 9 Domain Expertise Services (Clinical, Financial, and Operational) Analytics Applications: A robust set of applications, built on top of DOS, that generate meaningful insights for improvement 2 Data and Analytics Platform (DOSTM) : A healthcare-specific, open, flexible, scalable and self-service platform for analytics, app development & interoperability 1 Services Expertise: Analytical, clinical, financial, and operational experts facilitate and accelerate measurable improvement 3 Analytics Services (Data Analysts, Data Scientists, Pharmacoepidemiologists, and Data Engineers) Benchmarking Data (TouchstoneÔ) Activity-based Costing (PowerCostingÔ) Revenue Improvement & Chargemaster Analytics (VitalCDM®) Financial & Operational Patient Safety (Patient Safety MonitorÔ) Clinical Accelerators (CAUTI, CLABSI, COPD, Diabetes, Falls, Heart Failure, Joint Replacement, Labor and Delivery, Patient Flow, Pneumonia, Readmissions, Sepsis, Stroke, etc.) Clinical & Quality Care Management (Care FlowTM ) Pop Health Analytics (Pop AnalyzerTM, Stratify, Pop InsightsTM ) Quality and Regulatory Measures (MeasureAbleTM ) EMR Embedded Insights (Care Gaps & Refills) Population Health Life Sciences Terminology Services Text Processing Real-time Streaming & Interoperability Machine Learning Big Data Expert Data Collections Data Warehouse Cloud-based Source Connectors Reusable Data Logic Pop Health Strategy (Value OptimizerTM) Implementation Services Financial Accelerators (Cost Insights, HR System, Revenue Cycle, Supply Chain, Surgical Supply, etc.) Labor Productivity (PowerLaborTM) Revenue Integrity & Auditing (VitalIntegrityTM ) Patient Engagement (TwistleTM ) Health Catalyst Solution Price Transparency (Hospital Price IndexTM) Self-Service Analytics AI (Healthcare.AITM) Effective Use Expand Use Analytics (Pop AnalyzerTM) Reporting (Pop InsightsTM) Data Entry (IDEATM) Outsourced Services (Abstraction, Analytics, etc.) Health Catalyst Research NetworkTM Clinical Trials (Touchstone MatchTM ) Patient Engagement (TwistleTM) Real-World Data Registries (TouchstoneÔ)
- 10. © Health Catalyst. Confidential and proprietary. 10% of clinical trial sites never enroll a patient, 30% under enroll, and 20-25% never start The Clinical Trials Conundrum I. Need - Finding New Patient Sources and access a broad network of the patients, providers and data to recruit a larger potential patient pool. II. Need - Technologies within a health system have not been designed with clinical trial matching as a priority. IV. Need – Finding Relevant Data for faster time to first patient in/enrolled (FPI) in a clinical trial with certainty of patient eligibility and lower loss to follow- up patients, will allow trial to be executed more quickly III. Problem – Lack of diversity and ongoing patient engagement in clinical trials.
- 11. © Health Catalyst. Confidential and proprietary. Poll Question: What is the biggest challenge you see in the success of clinical trials? A. Trial design & feasibility using RWD – 7.7% B. Identifying and onboarding sites – 15.4% C. Patient recruitment – 46.2% D. Trial execution and completion – 15.4% E. Others – 15.4% 11
- 13. Our vision is to present world class solutions bringing insights to researchers' fingertips, which is derived from high-quality data and patient engagement, to expedite clinical trials and real-world evidence leading to optimal health for as many people as possible.
- 14. © Health Catalyst. Confidential and proprietary. 14 Clinical Research Across the Health Catalyst Client Network • Across 70+ Health Catalyst clients • 6900+ active clinical trials • >60% of all industry sponsored phase I-IV clinical trials are run across the network
- 15. ©2021 Health Catalyst Company Confidential 15 Impacting Clinical Development Cycle 15 Source: adapted from Blog Andrea Coravos Protocol design and review Site Selection & Start-Up (Contract) Patient Recruitment Operational Management Drug & Supply Logistics Trial Administration Patient-Level Data Collection Patient and Outcomes Data Management Digital Biomarker Collection Regulatory Submission Virtual Trials Start of the trial End of the trial HCAT Offerings Upcoming No HCAT Solutions Available/ Partnership Network Program
- 16. Touchstone MatchTM • A curated network of healthcare provider systems, biopharmaceutical companies, and contract research organizations (CROs). • Facilitates connections and collaboration to increase the efficiency, reach, and value of clinical research efforts. • Includes access to Touchstone data when you contribute a minimum viable data set. • Influences the development of Health Catalyst Life Sciences offerings. Our Approach to Clinical Trials Health Catalyst Research NetworkTM (HCRN) Patient-specific treatment regimens and clinical condition data support personalization of new or in-flight patient engagement pathways during clinical trials Health Catalyst products and services to support key research network use cases: Pop Analyzer: Application to quickly develop patient cohorts for clinical research. Touchstone: National repository of high-quality, research-grade healthcare data. Healthcare.AI Expert Services: Access to a team of data science experts who can guide the effective use of augmented intelligence (AI) in research use cases.
- 17. © Health Catalyst. Confidential and proprietary. Touchstone Match will transform patient identification for Clinical Trials and Real- world Insights and use Health Catalyst’s software application, vast health dataset and expertise so the right patients are identified faster for research. Key use cases Touchstone Match will allow: • Patient Cohort of Interest • Trial Design • Site Feasibility and ID • Synthetic Control Arm Solutions Description – Touchstone MatchTM Think of Match.com for Healthcare and Life Sciences Paid Subscribers Single Person Pharma CRO Health Systems Touchstone Match TM Health Catalyst Research Network Connecting >80M patients
- 18. © Health Catalyst. Confidential and proprietary. Introducing HCAT Research Network (HCRN) Mission Provide a forum for thought leadership and mutual knowledge exchange across provider systems, biopharma, contract research organizations, and other relevant stakeholders to transform care delivery and drug development research through next-gen insights. HCRN members collaborate internally and with the ecosystem of Touchstone Data & Insights under the direction of HCAT. Membership Benefits HCRN members enjoy a driving seat at the forefront of healthcare innovation, with thoughtful use of data to develop unique insights, incubation of research activities, revenue, and networking activities. 18 Clinical Research as a Care Option HCRN (Providers, Biopharma, CROs) Quality Data Platform
- 19. Twistle - Patient Engagement Platform 19
- 20. © Health Catalyst. Confidential and proprietary. 20 In Closing… • High value in research can be achieved with digital platforms powered by high quality data and connectivity to the patient • If you would like to find out more about Health Catalyst Solutions as well as the Life Sciences team, please reach out to us • Thank you! [email protected] A long queue of mountain climbers line a path on Mount Everest earlier this year