Next-Generation Sequencing Commercial Milestones Infographic
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The document outlines the evolution of next-generation sequencing (NGS) technologies and their commercial impacts from 2000 to 2016. It highlights the significant drop in sequencing costs, advancements made by various biotech companies, and the advent of direct-to-consumer genetic testing. Key milestones include the completion of the human genome project and the introduction of various sequencing platforms by companies like Illumina, Qiagen, and Pacific Biosciences.
Next-Generation Sequencing Commercial Milestones Infographic
- 1. Pacific Biosciences is founded to commercialize Single Molecule Real Time (SMRT) sequencing Helicos Biosciences is founded to commercialize Single Molecule Sequencing Lynx® , credited with massively parallel sequencing, merges with Solexa® leading to the development of sequencing-by-synthesis, used in most NGS platforms 454® releases the 454 Genome Sequencer (GS20) Complete Genomics (CG) founded to commercialize DNA nanoball sequencing technology 2003 2004 2005 2006 Next-Generation Sequencing Commercial Milestones Next-generation sequencing (NGS) has revolutionized the way we analyze diseases and commercial outfits such as Illumina, Helicos, QIAGEN and Pacific Biosciences have made significant contributions. In addition, the launch of direct-to-consumer genetic testing solutions has dramatically changed the way consumers access genomics data. Until a few years ago, the cost of sequencing was a major bottleneck. Recent developments have reduced the cost from thousands of dollars to a couple of cents per megabase. When did these changes start? What were the changes in the commercial sector in the last 15 years? This infographic is a timeline of the NGS commercial marketplace. Have you heard of the new QIAseq NGS solutions? A comprehensive array of NGS solutions starting from sample prep to data analysis and interpretation are now available to accelerate your research! For the latest on NGS, visit us at www.qiagen.com/qiaseq Sample to Insight Trademarks: QIAGEN® , Sample to Insight® , Ingenuity® , (QIAGEN Group); 23andMe® (23andMe Inc.); 454 Life Sciences® and 454 Genome Sequencer® (Roche Inc.); Ancestry® and AncestryDNA® (Ancestry Inc.); COLOR (Color Genomics Inc.); Counsyl® (Counsyl Inc.); GeneReader™ (Intelligent Bio-Systems, Inc.); Helicos Biosciences® , Helicos Genetic Analyzer® system, (Helicos Biosciences Inc); ABI® , Ion Torrent™, SOLiD System® (Thermo Fisher Scientific Inc.); Lynx Biosciences® (LynxBio Group); Solexa® , Genome Analyzer® , HiSeq® , NextSeq® , Illumina® (Illumina Inc); Mapmygenome® (Mapmygenome Inc.); Myriad Genetics® (Myriad Inc.);Oxford Nanopore® (Oxford Nanopore Inc.); Pacific Biosciences® , SMRT® (Pacific Biosciences Inc.); Positive Bioscience® (Positive Biosciences Inc.). Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not to be considered unprotected by law. © 2016 QIAGEN, all rights reserved The Mouse Genome Sequencing Consortium sequences the mouse genome and determines that humans share 99% of genes with mice The Human Genome Project Consortium completes sequencing the first draft of the human genome2001 2002 Gene By Gene® specialized in DNA-based ancestry and genealogy as Family Tree DNA 2000 23andMe is the first company to offer DNA analysis tools to help customers understand their genetic information and ancestral background Sequencing Cost/Megabase $5292.39 $3656.22 $2608.59 $1217.73 $884.39 $642.33 Ion TorrentTM founded to commercialize semi-conductor sequencing technology Illumina, a developer and maker of microarrays, acquires Solexa Life Technologies acquires Ion Torrent ABITM releases the SOLiDTM System Ray Wu, Columbia University scientist credited with the first method for determining DNA sequences, dies at 79 Solexa releases Genome Analyzer (Genome A), it‘s sequencing platform Oxford Nanopore Technologies showcases its ultra long single molecule sequencing technology Detection of inherited mutations for breast and ovarian cancer using targeted NGS Helicos releases the first single sequencer, Helicos Genetic Analyzer System Helicos Biosciences files for Chapter 11 bankruptcy QIAGEN acquires Ingenuity, a leader in the analysis and interpretation of complex biological data Illumina introduces the HiSeq® 2000 BGI-Shenzhen acquires Complete Genomics Fred Sanger, “Father of Genomics“ and the only British scientist to win 2 Nobel Prizes, dies at 95 Illumina introduces the HiSeq X Ten platform; delivering on their $1000/genome promise (requires 18,000 genomes are sequenced a year) 2007 2008 2009 2010 2011 2014 2012 2013 Illumina introduces the NextSeq® 500 platform, a desktop sequencer capable of sequencing whole genomes 2015 QIAGEN acquires Intelligent Bio-Systems (IBS) and enters the sequencing market Illumina introduces the HiSeq® 2500 Association for Molecular Pathology vs. Myriad Genetics is argued in the US Supreme Court; Myriad‘s patents on BRCA1/2 are deemed invalid QIAGEN acquires CLC bio, a leader in NGS bioinformatics QIAGEN introduces the GeneReaderTM sequencer—based on sequencing- by-synthesis technology 2016 Roche decides to close down 454 Life Sciences operations, after acquiring them 6 years earlier Counsyl offers DNA testing and genetic counseling advice direct to consumers Positive Bioscience offers cancer genomic and personal genomic tests direct to consumer Mapmygenome offers personal genomics, molecular diagnostics and DNA forensics direct to consumer FDA launches the PrecisionFDA platform: an online, cloud-based portal for NGS assay evaluation and regulatory science exploration QIAGEN launches QIAseqTM NGS Solutions technology Ancestry.com launches AncestryDNA Service: an affordable DNA test combined with the world‘s largest online family history resource $479.59 $32.33 $1.57/Mb $0.38 $0.16 $0.07 $0.06 $0.05 $0.05 $0.03 Seq Cost/Mb Direct-to-Consumer Test Markets Ancestry Athletic Carrier Child talent Genetic relation Infidelity Matchmaking Nutrigenic Paternity View the NGS Clinical Research Milestones Infographic Human Genome Project completes sequence of human genome (3.3 Gb) Color Genomics offers tests to understand the risk of hereditary cancers, direct to consumers