This document compares popular JavaScript automation frameworks for testing Node.js applications, including Protractor, WebdriverIO, and NightwatchJS. It provides details on each framework, such as supported features, syntax, and advantages. NightwatchJS is highlighted as a good option for end-to-end testing due to its built-in test runner, support for parallel testing, cross-browser testing, and mobile testing. While it requires callbacks, NightwatchJS has an easy syntax, inbuilt debugging, and is overall presented as a strong framework for end-to-end testing of Node.js applications.