Nicola Del Gobbo presented on developing Node.js native addons from scratch. Native addons allow integration of C/C++ code and libraries with Node.js for performance benefits. They can be loaded using require() but require special handling to interface with JavaScript. The presentation covered why to use native addons, how to structure a project, asynchronous programming, and interfacing with Node.js objects like EventEmitters and streams. Upcoming N-API will improve compatibility across Node.js versions and platforms.