PEGS Korea 2015 the essential protein engineering summit
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The PEGS Korea summit, held from September 1-3, 2015, at JW Marriott Seoul, focuses on protein and antibody engineering, featuring keynote presentations and discussions from leading scientists. The event aims to address challenges in reproducible research, antibody development, and therapeutic innovations in oncology and immunotherapy. With over 1800 participants expected, the summit highlights advancements in antibody design, delivery methods, and therapeutic enzyme development throughout its agenda.
PEGS Korea 2015 the essential protein engineering summit
- 1. SEPTEMBER 1-3, 2015 • JW MARRIOTT SEOUL, SOUTH KOREA Keynote Presentations: At the Crossroads: Getting to Reproducible Research Antibodies Andrew Bradbury, MBBS, Ph.D., Biosciences Division, Los Alamos National Laboratory Developing Antibodies against DifficultTargets Using Computational Approaches Gregory P. Adams, Ph.D., Director, Biological Research and Therapeutics, Fox Chase Cancer Center PEGS is Cambridge Healthtech Institute (CHI)’s flagship biologics meeting, and is widely considered the industry’s leading event on protein and antibody engineering. Its successful accolades include an annual attendance of over 1800 participants at the PEGS Summit in Boston, a record attendance of over 500 attendees at PEGS Europe last year, a successful launch of PEGS China in 2014, and now, we proudly announce PEGS Korea. This 3 day inaugural event will bring together an international faculty of scientists, professors and managers from leading universities, research laboratories and biopharmaceutical companies to share practical applications and case examples in protein and antibody engineering and novel biotherapeutics development. Cambridge Healthtech Institute Corporate SponsorPremier Sponsor Sponsoring Organizations PEGSummitKorea.com Register by May 1 & Save up to $600! Track 1 Protein & Antibody Engineering Track 2 Next- Generation Antibody Therapeutics
- 2. PEGSummitKorea.com TUESDAY, SEPTEMBER 1, 2015 7:30 am Registration and Morning Coffee 8:30 Chairperson’s Opening Remarks Junho Chung, Ph.D., Professor and Chairman, Biochemistry and Molecular Biology, Seoul National University KEYNOTE PRESENTATIONS 8:40 At the Crossroads: Getting to Reproducible Research Antibodies Andrew Bradbury, MBBS, Ph.D., Biosciences Division, Los Alamos National Laboratory, Researchers all over the world routinely use antibodies, a critical class of commercially supplied reagents that are frequently unreliable. This situation affects reproducibility in biomedical research, wastes millions of dollars annually, and may affect clinical trials. This talk will provide an overview of the problem, argue that the time has come to express antibodies recombinantly and refer to them by their sequences, and provide possible ways to get to this ideal. 9:20 Developing Antibodies against DifficultTargets Using Computational Approaches Gregory P. Adams, Ph.D., Director, Biological Research and Therapeutics, Fox Chase Cancer Center The most interesting functional targets are often highly conserved between species making them particularly difficult targets for antibody generation. I will discuss our approach to overcome prior failures of phage and immunization approaches by employing novel knowledge-based design strategies including homology modeling of the interaction of hormones and receptors, loop grafting and computational design. 10:00 Coffee Break TARGET DISCOVERY AND VALIDATION 10:30 Identification of NewTherapeuticTargets of Hepatocellular Carcinoma unpublished data Gwanghee Lee, Ph.D., Cancer Project Leader, Therapeutic Strategic Unit, Asia Pacific R&D, Sanofi Liver cancer is the second leading cause of cancer death in Korea and worldwide. However, the current treatment option is limited. With the advent of antibody engineering technique and cancer immunotherapy, target identification and validation become more important. To address the unmet medical needs, we have been implementing efforts to identify new therapeutic targets of hepatocellular carcinoma. Rationale, experimental design and preliminary data will be presented. BIOLOGICS TARGETING INTRACELLULAR PROTEINS 11:00 Delivering Antibodies into the Cell:Towards a NewTherapeutic Paradigm? unpublished data Stefan Duebel, Ph.D., Professor and Managing Director, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universitat Braunschweig, Germany We developed a systematic evaluation strategy and used it to identify the optimal way to deliver active antibodies into a living cell’s cytosol. We also generated the world’s first ER intrabody induced knockout mouse - offering a new approach for functional genomics, to validate targets, generate more relevant disease models and even try new strategies for therapeutic intervention. These approaches may very much accelerate the so far quite moderate progress in development of strategies targeting intracellular antigens with therapeutic antibodies. 11:30 Cytosol-Penetrating IgG Antibody and Its Application forTargeting Cytosolic Proteins Yong-Sung Kim, Ph.D., Professor, Department of Molecular Science & Technology, Ajou University, Korea Full-length IgG antibodies cannot cross cell membranes of living cells; this limits their use for direct targeting of cytosolic proteins. Here, we describe a general strategy for the generation of intact, full-length IgG antibodies, herein called cytotransmabs, which internalize into living cells and localize in the cytosol. Further, we will show that cytotransmab technology has practical applicability for direct targeting of cytosolic proteins. 12:00 pm Presentation to be Announced Sponsored by 12:30 Networking Luncheon in the Exhibit Hall with Poster Viewing (Sponsorship Opportunity Available) ANTIBODY LIBRARY CONSTRUCTION & DESIGN 1:55 Chairperson’s Remarks Yong-Sung Kim, Ph.D., Professor, Department of Molecular Science & Technology, Ajou University, Korea 2:00 Construction and Use of Large Antibody Libraries in Mammalian Cells John McCafferty, Ph.D., CEO, IONTAS Construction of libraries of binders displayed on the surface of mammalian cells will allow the screening of millions of clones by flow sorting while providing information on both the level of expression and the extent of binding within individual clones. The main limitation to achieving this has been the inability to construct large libraries containing a single antibody gene/cell. We have solved this problem by directing the integration of antibody genes into a single genomic locus through the use of site-specific nucleases. The presentation will describe construction of libraries of millions of clones and selection of binders including antibodies formatted as IgGs. 2:30 A Novel Approach to Synthetic Antibody Library Design: SCIEN Principle Hyunbo Shim, Ph.D., Assistant Professor, Department of Bioinspired Science, Ewha Womans University Most synthetic antibody libraries have sequence diversity generated by random combinatorial process. While capable of generating very large diversity, this inevitably introduces some undesirable and/or unnatural sequences to the library. In this presentation, a library with non-combinatorial CDR diversity based on SCIEN (Synthetic CDRs Inspired by and Emulating Nature) principle is described. The validity of this design approach was tested by panning on antigens, binding and kinetic assays, and next generation sequencing. 3:00 Detection and Correction of Errors and Biases in NGS of Antibody Repertoires Enables Improved Accuracy for Monoclonal Antibody Discovery Sai Reddy, Ph.D., Assistant Professor, Biomolecular Engineering, Department of Biosystems, ETH Zurich Next-generation sequencing (NGS) of antibody repertoires offers the promise to aid existing antibody discovery technologies such as hybridoma and phage/yeast display screening. We have developed a highly accurate experimental-bioinformatic pipeline for performing NGS-based analysis of antibody responses that enables detection and correction of systematic errors and biases in sequencing. Our new method thus allows for more accurate and reliable antibody repertoire data, which can be used for monoclonal antibody discovery. 3:30 Using Multiple Antibody Discovery Platforms to Sponsored by Overcome the Challenges in Developing Antibody Drug against Immune Check PointTargets Jing Li, M.D., Ph.D., MBA, Vice President, Biologics Discovery, WuXi AppTec The recent approvals of Pembrolizumab and Nivolumab, the two anti PD-1 antibodies, have attracted more attention to the immune check point targets. However the general protein sequence homology of those targets between human and mouse species is low, posing significant challenge on preclinical in vivo testing of such antibody drug candidates. We will show how to utilize different antibody discovery platforms to overcome the challenge and to expedite the drug discovery process. 4:00 Refreshment Break in the Exhibit Hall with Poster Viewing THERAPEUTIC ENZYME DEVELOPMENT 4:45 Molecular Engineering to Improve theTherapeutic Potential of the Enzyme L-Asparaginase Used for theTreatment of Leukemia Manfred Konrad, Ph.D., Professor, Research Director, Enzyme Biochemistry, Max Planck Institute for Biophysical Chemistry The therapeutic effect of the clinically established enzyme drug L-asparaginase (L-ASNase) relies on the fact that cancerous lymphoblasts depend on the supply of free L-asparagine from the blood. FDA-approved L-ASNases are of bacterial origin, despite eliciting severe side effects, in particular immunogenicity. We pursue the design of catalytically improved human ASNases and microencapsulation of the enzyme, thus enhancing serum stability and suppressing recognition by the immune system. Track 1 September 1-2, 2015Protein & Antibody Engineering
- 3. 5:15 NovelTherapeutic Proteins Derived from Human Protein Synthesis Machinery Sunghoon Kim, Ph.D., Professor and Director, Medicinal Bioconvergence Research Center, Molecular Medicine and Biopharmaceutical Sciences, Seoul National University Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for cellular protein synthesis. However, they play diverse physiological roles in extracellular space and their activities show potential for novel therapeutic applications. The extracellular functions of this group of proteins are rapidly being unveiled recently and they are expected to become a resource for novel therapeutic agents. In this context, it is timely and critical to introduce new biology and biopharmaceutical application of these proteins. 5:45 Welcome Reception in the Exhibit Hall with Poster Viewing 6:45 Close of Day One WEDNESDAY, SEPTEMBER 2, 2015 7:45 am Registration and Morning Coffee ENGINEERING FOR IMPROVED PROPERTIES AND THERAPEUTIC POTENTIAL 8:30 Chairperson’s Opening Remarks William (Jonny) Finlay, Ph.D., Director, Protein Discovery & Optimization, Global Biotherapeutics Technologies, Pfizer Ireland 8:40 Beyond Antibodies: Rational Design of Oncology Biotherapeutics with Improved Activities Alexey Lugovskoy, Ph.D., Vice President, Therapeutics, Merrimack Pharmaceuticals 9:10 Single-Step Ultra-Humanization, Stabilization and Essential Paratope Sampling of Murine, Avian and Leporid IgGs William (Jonny) Finlay, Ph.D., Director, Protein Discovery & Optimization, Global Biotherapeutics Technologies, Pfizer Ireland This study presents a technology that generates stable, soluble, ultra-humanized antibodies via single-step CDR redundancy minimization. Lead clones demonstrated high stability, with affinity and specificity equivalent to, or better than, the parental immunoglobulin. This significantly lowered non-human sequence content, minimized t- and b-cell epitope risk in the final molecules and provided a heat map for the essential non-human CDR residue content of antibodies from disparate sources. 9:40 Engineering Aglycosylated Full-Length IgG Antibodies for Next Generation Immunotherapeutics unpublished data Sang Taek Jung, Ph.D., Professor, Department of Bio and Nano Chemistry, Kookmin University Aglycosylated IgG antibodies shows almost same antigen binding affinity, serum half- life, and biodistribution compared to glycosylated counterpart. However, the removal of N-linked glycan at Asn297 of IgG Fc causes significant change of conformational dynamics and abolishes antibody Fc-mediated effector functions. To restore or enhance therapeutic effector functions, aglycosylated Fc region has been extensively engineered and sets of aglycosylated Fc variants exhibiting novel FcγR binding specificity and unique therapeutic effector functions have been isolated. 10:10 Coffee Break in the Exhibit Hall with Poster Viewing 10:50 A Single-Chain Fragment against Prostate Specific Membrane Antigen as aTool to BuildTheranostic Reagents for Prostate Cancer Mariangela Figini, Ph.D., Head, Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori Milano In this research we use a single-chain variable fragment (scFv) directed against Prostate Specific Membrane Antigen (PSMA), over expressed in prostate cancer, for therapeutic targeted approaches. A murine anti-PSMA mAbs D2B was converted in a scFv analyzed in vitro and in vivo for its ability to detect or kill prostate cancer cells. Different approaches for humanization of the scFv have been applied and we propose it as a theranostic reagent. 11:20 Design of Less Immunogenic Drugs Using in silico and in vitroTools Sofie Pattijn, CTO, ImmunXperts The rapid and exponential growth of therapeutics has also exposed a number of new challenges in drug design and development. One of the major hurdles is the potential of the drug to induce an unwanted immune response. The use of in silico algorithms and in vitro T cell proliferation assays can guide the design of less immunogenic drugs and support the selection of those candidates with the lowest immunogenicity risk. 11:50 Sponsored Presentation (Opportunity Available) 12:20 pm Networking Luncheon in the Exhibit Hall with Poster Viewing (Sponsorship Opportunity Available) 1:30 End of Protein & Antibody Engineering PEGSummitKorea.com Track 1 September 1-2, 2015Protein & Antibody Engineering WEDNESDAY, SEPTEMBER 2, 2015 1:00 pm Registration CANCER IMMUNOTHERAPEUTICS 1:30 Chairperson’s Opening Remarks Ho Cho, Ph.D., CSO, Celgene Therapeutics 1:40 New Horizons in Immuno-Oncolgy: Beyond Check-Point Inhibitors Ho Cho, Ph.D., CSO, Celgene Therapeutics The recent convergence of enabling technologies with a fundamentally better understanding of the immune system has resulted in new treatment paradigms with unprecedented efficacy for many patients. Building on this success requires an integrated view of the immune system and the tumor microenvironment. This presentation will highlight our recent work on leveraging the innate immune system with an anti-CD47 mAb. 2:10 Engineering Multiple Immune Checkpoint Blockades for Cancer Therapy Cheng-I Wang, Ph.D., Principal Investigator, Therapeutic Antibody Engineering, Singapore Immunology Network Although anti-PD-1 antibodies have shown encouraging clinical outcomes, only 15-40% of patents of various cancers respond to the therapy. Hence, how to further enhance anti-cancer efficacy of immune checkpoint blockade has become an active research. Here we would like to address this problem by an antibody engineering approach, aiming at generating synergistic effects by dual pathway blockade. 2:40Targeting the Intracellular Proteome withT-Cell Receptor-Like Antibodies Yoram Reiter, Ph.D., Professor & Head, Laboratory of Molecular Immunology, Technion- Israel Institute of Technology The ability to generate t-cell receptor-like (TCRL) antibodies which bind HLA-peptide complexes on the surface of cells opens new possibilities for developing new therapeutic modalities. These antibodies can bind specifically to, and kill, the diseased cells, transforming disease-specific targets expressed inside malignant cells into targets that can be recognized on the cell surface by soluble TCRL antibodies. This approach expands the pool of novel therapeutic antibodies beyond the limits of currently available antibodies. 3:10 Sponsored Presentation (Opportunity Available) 3:40 Refreshment Break in Exhibit Hall with Poster Viewing ANTIBODIES FOR CANCER THERAPY 4:20 Combination of Novel HER2Targeting Antibody 1A12 with Trastuzumab Shows Synergistic Antitumor Activity in HER2 Positive Gastric Cancer Kyu-Tae Kim, Ph.D., Director, ADDs, AbClon, Inc. The synergistic interaction of two antibodies targeting the same protein can be developed as an effective anti-cancer therapy. We describe the development of 1A12, a HER2-targeted monoclonal antibody showing increased efficacy in a highly synergistic manner in combination with trastuzumab. The synergistic antitumor activity of 1A12 in combination with trastuzumab indicates that it could be a novel potent therapeutic antibody for the treatment of HER2-overexpressing gastric and breast cancers. 4:50 Next-GenerationTherapeutic Antibody Inhibiting Epithelial Ovarian Cancer Metastasis Sukmook Lee, Ph.D., Principal Investigator, Research Center, Scripps Korea Antibody Institute Ovarian cancer metastasis is a complex phenomenon resulting from the coordinated action of many metastatic regulators and must be overcome to improve clinical outcomes for patients with these cancers. Here, we first show the functional relevance between TSPAN8-LEL and ovarian cancer metastasis. By generating a human IgG antibody specific to TSPAN8-LEL, we demonstrate its mode of action, in vivo efficacy, and toxicity. Collectively, these data suggest that an antibody to TSPAN8-LEL may have therapeutic potential for the treatment of ovarian cancer metastasis. Next-Generation Antibody TherapeuticsTrack 2 September 2-3, 2015
- 4. PEGSummitKorea.com 5:20 Action Mechanism-Guided Competitiveness Design of GC1118, A Novel Anti-EGFR Antibody unpublished data Jonghwa Won, Ph.D., Senior Research Director, Oncology Team, Mogam Biotechnology Institute EGFR antibodies currently in development are quite different in their forms ranging from antibody mixtures to drug conjugates, action mechanism, and target disease areas. GC1118 has a distinct binding epitope and shows a big difference in the spectrum of EGFR ligands and cancer cell types that are inhibited. Potential hypothesis in working mechanism and clinical implications of GC1118 will be presented. 5:50 End of Day THURSDAY, SEPTEMBER 3, 2015 8:00 am Morning Coffee BISPECIFIC ANTIBODIES 8:30 Chairperson’s Opening Remarks Jin-San Yoo, Ph.D., CEO, President & Founder, PharmAbcine 8:40Therapeutic Applications of DART® Proteins Syd Johnson, Ph.D., Vice President, Antibody Engineering, MacroGenics, Inc. Bispecific antibodies represent a highly potent class of immunotherapeutic agents that may outperform or complement traditional chemotherapy, naked antibodies and ADCs. MacroGenics’ Dual-Affinity Re-Targeting (DART) proteins are among the most stable and potent biologics in this therapeutic class. This talk will highlight several DART proteins currently in clinical studies and those entering clinical studies, as well as new formats and specificities that are under development for future drug candidates. 9:10 Clinical and Preclinical Development on DVD-Ig Dual-Specific Molecules and Next-Generation Multi-Specific Molecules Tariq Ghayur, Ph.D., Senior Research Fellow & Principal Scientist, Abbvie Bioresearch Center The DVD-Ig formats enable us to combine the target binding domains of 2 mAbs in a single molecule. Four DVD-Ig molecules are now in clinical development in autoimmune and oncology indications. In this talk I will provide an update on two DVD-Ig molecules in clinical development (RA and OA). In addition, I will discuss recent preclinical developments in extending our multi-specific platforms to address specific unmet clinical needs. 9:40 Clinical Development ofTanibirumab and Next-Generation Bispecific Antibodies Jin-San Yoo, Ph.D., CEO, President & Founder, PharmAbcine Tanibirumab, anti-KDR neutralizing fully human IgG1 with unique cross species cross reactivity is in Phase II recurrent GBM trial. I will cover its Phase I data, Phase II protocol for GBM trial and update of Phase II study. PMC-001 (=DIG-KT), next generation of bispecific antibody neutralizing both VEGF-KDR and ANG-TIE2 pathways is in preclinical stage and I will cover the progress report. PMC-008b, anti-EGFRvIII specific huma IgG1 for ADC and CAR-T will be introduced. 10:10 Coffee Break in the Exhibit Hall with Poster Viewing 10:40 A Novel DualTargeting Inhibitor to VEGFR-TIE2 unpublished data Mohit Trikha, Ph.D., CSO, Executive Vice President and Head, R&D,, Triphase Accelerator Anti-angiogenic agents such as bevacizumab (anti-VEGF) and ramicirumab (anti-VEGFR2) have proven effective in the treatment of solid tumors. However, tumors can escape the effects of these agents through the TIE-2 axis, activated by angiopoietin. TRPH011 is a dual targeting biologic that blocks both VEGFR2 and TIE2 pathways. The talk will cover in vitro and in vivo activity of TRPH 011 and our approach to developing dual targeting anti-angiogenic agents. 11:10 A Novel Bispecific AntibodyTargeting VEGF and DLL4 Inhibits Tumor Progression unpublished data Weon-Kyoo You, Principal Research Scientist, Biologics Unit, Hanwha Chemical Hanwha has developed a unique novel bispecific antibody targeting VEGF and DLL4. The bispecific antibody has similar activities by various in vitro assays compared to VEGF or Dll4-single targeting antibody. In addition, the bispecific antibody more effectively inhibits tumor progression in several xenograft models. These results suggest Hanwha’s bispecific antibody could be further developed as a potent anti-cancer therapeutic antibody. 11:40 An Open Cell-Free Protein Synthesis Platform to Discover Novel Antibodies and Bispecifics Aaron Sato, Ph.D., Vice President, Research, Sutro Biopharma, Inc. Using our cell free expression platform, Sutro can quickly discover novel antibody fragments (e.g. scFv and Fabs) to any relevant disease target using ribosome display with our bacteria extract system. Finally, we can reformat these antibody leads in a many different bispecific frameworks and test them for binding and functionality. Several case studies will be presented to exemplify the power of this system for antibody and bispecific discovery. 12:10 pm Sponsored Presentation (Opportunity Available) 12:40 Networking Luncheon in the Exhibit Hall with Poster Viewing (Sponsorship Opportunity Available) ANTIBODY-DRUG CONJUGATES 1:45 Chairperson’s Remarks Byoung-Chul Lee, Ph.D., Scientist, Protein Chemistry, Genentech, Inc. 1:50 Improvement of theTherapeutic Index of Amanitin-Based ADCs unpublished data Andreas Pahl, Ph.D., CEO, Heidelberg Pharma Amanitin-based ADCs represent a new class of ADCs using a novel MOA, inhibition of RNA pol II. The high potency of the toxin leads to highly efficacious ADCs. Here we present the development of technologies and strategies to improve the therapeutic index from the safety point of view. These developments support the clinical development of amanitin-based ADCs by using a toxin with a new MOA and with a favorable therapeutic index. 2:20 Antibody-Drug ConjugatesTargeting Embryonic and Pluripotent Stem Cell Markers as NovelTherapeutics for Metastatic Cancers Michael Schopperle, Ph.D., CEO, CureMeta Recent research studies are suggesting metastatic and aggressive cancers are caused by normal cells dedifferentiating or “reprogramming” backwards to an embryonic or pluripotent stem cell state. We have developed several antibodies which are specific for pluripotent stem cells markers and have made several ADCs as novel therapeutics for metastatic cancers. Our studies show that our new ADCs are specific for and highly efficient at killing pluripotent cancer stem cells. 2:50 Imaging Intracellular Activity of Antibody-Drug Conjugates case study unpublished data Byoung-Chul Lee, Ph.D., Scientist, Protein Chemistry, Genentech, Inc. Despite the recent success of ADCs, their mechanisms of action are not fully understood. In order to gain further understanding of the ADC intracellular uptake and payload release, we developed a novel fluorescence resonance energy transfer (FRET) ADC. This FRET assay will provide a facile and robust assessment of the intracellular processing and have significant implications for the future development and clinical use of ADCs. 3:20 Refreshment Break 3:30 NexMabTM , A Site-Specific Antibody-Drug Conjugation Method by Utilizing Ligand-Protected Cysteine-Containing Motifs, and Its Application to Herceptin-Drug Conjugate Soon Jae Park, Ph.D., CEO, Alteogen, Inc. We have developed a ligand-protected peptide motifs containing cysteine residues at the C-terminus of antibody heavy chain. This conjugation method, NexMabTM ,, was applied to Trastuzumab (Herceptin®). The resulting drug conjugated mAb (ALT-P7) showed that it did not perturb the stability of the mAb and exhibited a lower aggregation propensity compared with Kadcyla® (ado-trastuzumab emtansine). In mouse Xenograft study with BT-474 breast cancer cell, ALT-P7 displayed higher in vivo efficacy compared with Kadcyla®. 4:00 ConjuallTM Site-Specific Homogenous ADC Platform with a Novel Linker Chemistry Jeiwook Chae, Ph.D., Vice President, Biology, Legochem This presentation illustrates a novel linker chemistry combined with the enzymatic conjugation and shows superb plasma stability. The therapeutic potential of our homogenous ADCs shows improved pharmacokinetics and sustained long-term stability of DAR in rat and monkey as well as high potencies of tumor killing in vitro and in vivo. This data suggests that ConjuallTM ADCs display improved therapeutic indexes and will provide a new clinical opportunity for cancer patients in the future. 4:30 End of Conference Next-Generation Antibody TherapeuticsTrack 2 September 2-3, 2015
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- 6. ADDITIONAL REGISTRATION DETAILS Each registration includes all conference sessions, posters and exhibits, food functions, and access to the conference proceedings link. Handicapped Equal Access: In accordance with the ADA, Cambridge Healthtech Institute is pleased to arrange special accommodations for attendees with special needs. All requests for such assistance must be submitted in writing to CHI at least 30 days prior to the start of the meeting. To view our Substitutions/ Cancellations Policy, go to http://www.healthtech.com/regdetails Video and or audio recording of any kind is prohibited onsite at all CHI events. A series of diverse reports designed to keep life science professionals informed of the salient trends in pharmaceutical technology, business, clinical development, and therapeutic disease markets. For a detailed list of reports, visit InsightPharmaReports.com, or contact Adriana Randall, [email protected], +1-781-972-5402. Pricing and Registration Information CONFERENCE PRICING BASIC PACKAGE (Includes access to one conference track) Commercial Academic, Government, Hospital-Affiliated Early-Bird Rates until May 1 $1,199 $549 Early rates until June 5 $1,399 $649 Advance rates July 24 $1,599 $729 After July 24 and onsite $1,799 $799 STANDARD PACKAGE (Includes access to two conference tracks) Early-Bird Rates until May 1 $1849 $929 Early rates until June 5 $2,049 $1,029 Advance rates July 24 $2,199 $1,099 After July 24 and onsite $2,399 $1,149CONFERENCDIS Poster Submission - Discount ($50 Off): Poster abstracts are due by July 24, 2015. Once your registration has been fully processed, we will send an email containing a unique link allowing you to submit your poster abstract. If you do not receive your link within 5 business days, please contact [email protected]. *CHI reserves the right to publish your poster title and abstract in various marketing materials and products. Antibody Society and Protein Society Member Discount: CHI is pleased to offer The Antibody Society and The Protein Society Members a 20% discount to attend. Records must indicate you are a member at time of registration. Please Note - Discounts may not be combined. REGISTER 3 - 4th IS FREE: Individuals must register for the same conference or conference combination and submit completed registration form together for discount to apply. Alumni Discount: Cambridge Healthtech Institute (CHI) appreciates your participation at past events. As a result of the great loyalty you have shown us, we are pleased to extend to you the exclusive opportunity to save an additional 20% off the registration rate. Group Discounts: Discounts are available for multiple attendees from the same organization. For more information on group rates contact David Cunningham at +1-781-972-5472 If you are unable to attend but would like to purchase the PEGS KOREA CD for $500 (plus shipping), please visit PEGSummitKorea.com. Massachusetts delivery will include sales tax. How to Register: PEGSummitKorea.com [email protected] • P: 781.972.5400 or Toll-free in the U.S. 888.999.6288 Please use keycode ABK F when registering! Complimentary news delivered to your inbox Subscribe to New Bulletins or the Weekly Update Newsletter at Bio-ITWorld.com Clinical Trials to the Clinic, subscribe at ClinicalInformaticsNews.com Barnett is a recognized leader in clinical education, training, and reference guides for life science professionals involved in the drug development process. For more information, visit barnettinternational.com. Sponsoring Publications Web Partners Media Partners Lead Sponsoring Publications Cambridge Healthtech Institute 250 First Avenue, Suite 300, Needham, MA 02494 www.healthtech.com • Fax: 781-972-5425 Stay Connected