PharmAust: A Leader In Pharmaceutical Research & Discovery
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PharmAust is a clinical-stage oncology company focused on drug repurposing. Its lead product PPL-1 (Monepantel-MPL) successfully completed Phase I/II trials and is now Phase II ready. MPL has potential as a new class of targeted anti-cancer therapy. PharmAust also has a profitable specialty chemicals business and options for veterinary cancer applications through partnerships. The company is significantly undervalued given its pipeline and clinical progress.
PharmAust: A Leader In Pharmaceutical Research & Discovery
- 1. Investor Presentation January 2016 ASX: PAA ACN 094 006 023 1
- 2. Disclaimer DISCLAIMER This presentation has been prepared by PharmAust Limited (ASX: PAA) (ACN: 094 006 023) (the “Company”). It does not purport to contain all the information that a prospective investor may require in connection with any potential investment in the Company. You should not treat the contents of this presentation, or any information provided in connection with it, as financial advice, financial product advice or advice relating to legal, taxation or investment matters. No representation or warranty (whether express or implied) is made by the Company or any of its officers, advisers, agents or employees as to the accuracy, completeness or reasonableness of the information, statements, opinions or matters (express or implied) arising out of, contained in or derived from this presentation or provided in connection with it, or any omission from this presentation, nor as to the attainability of any estimates, forecasts or projections set out in this presentation. This presentation is provided expressly on the basis that you will carry out your own independent inquiries into the matters contained in the presentation and make your own independent decisions about the affairs, financial position or prospects of the Company. The Company reserves the right to update, amend or supplement the information at any time in its absolute discretion (without incurring any obligation to do so). Neither the Company, nor its related bodies corporate, officers, their advisers, agents and employees accept any responsibility or liability to you or to any other person or entity arising out of this presentation including pursuant to the general law (whether for negligence, under statute or otherwise), or under the Australian Securities and Investments Commission Act 2001, Corporations Act 2001, Competition and Consumer Act 2010 or any corresponding provision of any Australian state or territory legislation (or the law of any similar legislation in any other jurisdiction), or similar provision under any applicable law. Any such responsibility or liability is, to the maximum extent permitted by law, expressly disclaimed and excluded. Nothing in this material should be construed as either an offer to sell or a solicitation of an offer to buy or sell securities. It does not include all available information and should not be used in isolation as a basis to invest in the Company. FUTURE MATTERS This presentation contains reference to certain intentions, expectations, future plans, strategy and prospects of the Company. Those intentions, expectations, future plans, strategy and prospects may or may not be achieved. They are based on certain assumptions, which may not be met or on which views may differ and may be affected by known and unknown risks. The performance and operations of the Company may be influenced by a number of factors, many of which are outside the control of the Company. No representation or warranty, express or implied, is made by the Company, or any of its directors, officers, employees, advisers or agents that any intentions, expectations or plans will be achieved either totally or partially or that any particular rate of return will be achieved. Given the risks and uncertainties that may cause the Company’s actual future results, performance or achievements to be materially different from those expected, planned or intended, recipients should not place undue reliance on these intentions, expectations, future plans, strategy and prospects. The Company does not warrant or represent that the actual results, performance or achievements will be as expected, planned or intended. US DISCLOSURE This document does not constitute any part of any offer to sell, or the solicitation of an offer to buy, any securities in the United States or to, or for the account or benefit of any “US person” as defined in Regulation S under the US Securities Act of 1993 (“Securities Act”). The Company’s shares have not been, and will not be, registered under the Securities Act or the securities laws of any state or other jurisdiction of the United States, and may not be offered or sold in the United States or to any US person without being so registered or pursuant to an exemption from registration including an exemption for qualified institutional buyers. 2
- 3. Proprietary Technology pipeline of clinical-stage oncology drugs – focus on drug repurposing - new class of targeted therapy Lead product PPL-1 (Monepantel-MPL) successfully completed Phase I/II – now Phase II ready “New Class of Broad Spectrum Targeted Anti-Cancer Drug” Option with Novartis Animal Health for veterinary cancer applications Parallel development track with both human and veterinary applications Joint patents with large Japanese chemical/pharma – Nihon Nohyaku Pipeline products Mucin and Albendazole will be developed with partners Epichem - profitable business, forecast to achieve sales of AU$2.6M (US$1.8) in 2016 Corporate Overview ASX: PAA 3
- 4. ASX Code PAA ACN 094 006 023 Total Shares on Issue 92,503,645 Unlisted Options on Issue 675,000 Market Cap US$7.4M Cash (mrq) US$1.25M Debt (mrq)1 US$500,000 Sales (ttm) US$1.8M (AU$2.6M) Financial Snapshot Data as of January 11, 2016 1 EFIC loan to Epichem ASX: PAA
- 5. Significantly undervalued – substantial investor upside MPL proven to be active in Phase I trial Epichem Business enjoying growing revenues – forecast $10M by 2020 Potential for multi-billion dollar assets MPL already approved for veterinary application (Novartis Animal Health) Very tight capital structure - US$7.4M market cap Low enterprise value and significant leverage to success Proven management ASX: PAA Investment Highlights 5
- 6. $10M sales forecasted by 2021 Support for MPL program Phase II with MPL and Accelerate Commercialization Partnering Albendazole and Mucin projects Multiple Key Performance Drivers in 2016 ASX: PAA Capital Growth MPL-Phase II Success Phase III Ready Contract Business Meeting Sales Targets 6
- 7. $100B1 Surgery Radiation Targeted Therapy Hormonal Chemo Stem Cell 1 Reuters MPL is a New Targeted Therapy within the $100B Cancer Treatment Market Targeted Therapy Typically small molecules or monoclonal antibodies ASX: PAA MPL 7 1
- 8. 1. Safety – Excellent safety profile as predicted from pre-clinical models 2. Active dose – Identified dosage of MPL from effects on cancer markers in man 3. Efficacy – Determined efficacy by markers and effects on tumours (p70s6K and p4E-BP-1) 4. Synergy – Demonstrated synergy with many cytotoxic drugs currently in use 5. Cost – Showed optimal use of funds MPL Achieved All Key Phase I Endpoints ASX: PAA 8
- 9. Strong Confidence in Phase II Performance of MPL Substantial pre-clinical package in cancer models Substantial pre-clinical package as MPL on market with global major (Novartis Animal Health) Activity in naturally occurring canine cancers Activity in a range of human cancers (Royal Adelaide Hospital) – broad spectrum potential Synergy with existing standards of care mTOR - Mechanism now a major target for industry Other mTOR inhibitors generating billion dollar sales ASX: PAA 9
- 10. Implications for MPL As a new class of cancer drug with a novel mechanism of action it provides the opportunity to be effective where “Standard of Care” has failed Preclinical studies show reversal of drug resistance and synergy with chemotherapy, thus potential for combination therapy Novel mechanism of action (mTOR – autophagy) potentially circumvents resistance points of known drugs The very low toxicity of MPL avoids the dosing-limitations and toxicities of many approved anticancer drugs MPL Active in Phase I Trial in Patients Who Fail Other Available Treatments ASX: PAA 10
- 11. MPL Already Approved for Veterinary Applications Novartis Animal Health registered Zolvix (MPL) for the treatment of parasitic diseases in animals Extensive manufacturing and toxicology already established by global major pharma company Over 80 MPL analogues are available for development and accessible to PharmAust PharmAust holds patents on the use of MPL and other amino- acetonitriles (AADs) in cancer Epichem has synthesized further novel compounds ASX: PAA 11
- 12. Elevated p70s6k is Associated with Poor Outcomes in Cancer ASX: PAA Rapamycin-based Rapamune (Pfizer) & Afinitor (Novartis) both inhibit p70s6K and interfere with mTOR, generating billions in sales Patients who have a poor response to chemotherapy have high p70s6k levels p70s6k has been implicated to promote malignant transformation of cancers Rapamycin-sensitive p70s6k pathway is a potential novel target for therapeutic intervention in small cell lung cancer Overexpression of p70S6K in breast cancer patients is associated with aggressive disease and poor prognosis Patients with breast cancer with increased p70s6k phosphorylation have poor survival and increased metastasis 12
- 13. mTOR pathway depiction by: Marc Dufour, Anne Dormond-Meuwly, Nicolas Demartines and Olivier Dormond Cancers 2011, 3, 2478-2500; doi:10.3390/cancers3022478 High s6k Correlates with Multiple Negative Outcomes High s6k (p70s6k) in patients correlates with: Resistance to therapy Aggressive disease Poor prognosis High metastasis ASX: PAA Two complexes of mTOR (mammalian target of rapamycin) Cell Growth & Proliferation Cell Survival & Proliferation PRAS40 Raptor Deptor GβL mTOR Protor Rictor Deptor GβL mTOR mSin1 S6K4EP1 MPLMPL Akt PKCα SGK mTORC1 mTORC2 13
- 14. R 01 R 101 R 02 R 102 R 202 R 03 P A08 0 50 100 D e term in a tio n o f p -P 70 S 6 K in P B M C o f p atie n ts trea te d w ith M P L p-P70S6K (%control) D ay 1 before treatm ent D a y 3 D a y 7 ** ** ** *** **** ****** * Day 1 vs. Day 3 Yes *** 0.0004 Day 1 vs. Day 7 Yes ** 0.0020 COMPARISON SIGNIFICANT p-VALUE 1 Poor compliance over time due to extremely bad taste of drug 1 Suppression of p70s6k by MPL in Humans ASX: PAA 14
- 15. R 01 R 101 R 02 R 102 R 202 P A08 0 50 100 150 D eterm in atio n o f p -4E -B P 1 in P B M C o f p atien ts trea ted w ith M P L p-4E-BP1 (%control) D ay 1 before treatm ent D a y 3 D a y 7 ** * ** ** Day 1 vs. Day 3 Yes * 0.0440 Day 1 vs. Day 7 No ns 0.6086 COMPARISON SIGNIFICANT p-VALUE 1 1 Poor compliance over time due to extremely bad taste of drug Suppression of p-4E-BP1 by MPL in Humans ASX: PAA 15
- 16. 0 d a y 3 d a y s 7 d a y s 0 2 5 5 0 7 5 1 0 0 1 2 5 Control% P -p 7 0 S 6 K E lis a in d o g (M o rtim e r C a m b e ll) P B M C M P L T re a tm e nt 0 d a y 3 d a y s 0 2 5 5 0 7 5 1 0 0 1 2 5 P -p 7 0 S 6 K E lis a in d o g P B M C Control% M P L tre a tm e n t Suppression of p70s6k by MPL in Canines MPL Treatment MPL Treatment P-p70s6k Elisa in dog PBMC Relapse Lymphoma P-p70s6k Elisa in dog (Mortimer Cambell) PBMC Relapse Lymphoma ASX: PAA 16
- 17. mTOR Inhibition Anti- Estrogens Radiation Anti- Angiogenics GF Signaling Inhibitors Chemo mTOR Inhibition May Enhance Antitumor Effects of Other Therapies ASX: PAA 17
- 18. Synergy Between MPL & Cytotoxic Drugs1 Provides Potential for Combination Therapy 1 Synergy demonstrated on ovarian cancer grown in xenograft-mice ASX: PAA 18
- 19. PharmAust Novartis Animal Health Nihon Nohyaku Joint patent with Japanese major Option on veterinary cancer applications Commercialization of MPL (strong IP position) ASX: PAA 19
- 20. Experienced Management Dr. Roger Aston, Executive Chairman Previously at Wellcome Research Laboratories, Peptech, Cambridge Antibody Technology, QinetiQ, pSivida, Clinuvel, HalcyGen and Ascent Pharma Health. More recently CEO of Mayne Pharma Group. Robert Bishop, Executive Director 30 years’ experience in corporate finance and equity. Dr. Wayne Best, Director Nearly 30 years’ experience in synthetic and medicinal chemistry both in academia, government and industry. Sam Wright, Director & Company Secretary Over 15 years’ experience in the pharmaceutical, biotech and healthcare industry. ASX: PAA
- 21. SAM WRIGHT Director & Company Secretary [email protected] Phone: 61 (0) 408 900 277 DR ROGER ASTON Managing Director [email protected] Phone: 61 (0) 402 762 204 ASX: PAA ACN 094 006 02321