PPT_on_Vitamin_k_01.pptx
- 1. Government Holkar (Model Autonomous) Science College, Indore (M.P.) (NAAC Accredited "A" Grade College) Established : 1891 Department of Microbiology Topic :- Fat Soluble Vitamin K Guided by :- Dr. Neetu Mam Presented By :- ManDakni Singh Msc 1st sem
- 2. Vitamin Vitamin K Summary Types of vitamin k Sources of Vitamin K Functions of Vitamin K Functions of Vitamin K in BLOOD Functions of Vitamin K in BONE Absorption, Transportation and Storage Metabolism RDA Symptoms of Vitamin K Deficiency Reference INDEX
- 3. Vitamins are one of several substance that are found in certain type of food and that are improving for growth and good health They are required for normal cell function growth and development These micronutrients are not produced in our bodies and must be derived from food we eat vitamins are organic substance Classification of vitamins In humans there are 13 vitamins 4 fat soluble ( A D E and K ) and 9 water soluble ( 8B vitamins and vitamin C ) Vitamin
- 4. Vitamin k is a group of lipophilic and hydrophobic vitamins. Fat soluble compound necessary for the synthesis of several proteins required for blood clotting. (“K” is derived from the German word “koagulation”) Vitamin K
- 5. Vitamin K is a fat soluble vitamin. Phylloquinone, Menaquinone and Menadione are the members of vitamin K family. Plays an important role in blood clotting, bone formation and prevention of calcification of soft tissues. Deficiency of vitamin K is manifested in the form of bleeding tendencies and hemorrhages. Oral or injectable vitamin K can be recommended depending upon the severity of the disease. Summary
- 6. Types of vitamin k
- 7. Intestinal bacterial synthesis meets the daily requirement of vitamin K even without dietary supplement. Sources of Vitamin K Phylloquinone: Green leafy vegetables. Menaquinone: Intestinal bacteria. Menadione: synthetic form vegetable oil.
- 8. Coenzyme for the synthesis of prothrombinand bloodclottingfactors in the liver. Prothrombin andclotting factorsare proteinin nature. Matureprothrombin and clottingfactors contain g-carboxyglutamate aftercarboxylationreaction. VitaminK is essential forthe carboxylase enzymeinvolved. Dihydroquinoneformof vitaminK is essentialfor this reaction. Functions of Vitamin K
- 9. It is necessary for coagulation. They all are synthesized as inactive. zymogen form in the liver. Gamma carboxylation of glutamic acid residues. These are the binding sites for calcium ions. Vitamin K is required for proper bone health. Vitamin K is also required for the carboxylation of glutamic acid residues of osteocalcin, a Ca2+ binding protein present in bone. Functions of Vitamin K in BONE Functions of Vitamin K in BLOOD
- 10. Absorptiontakesplace insmall intestinein the presenceof bile salts. The transportationfrom intestine iscarriedout throughchylomicrons. Storageoccurs in liver andfrom liver transportationto peripheralcells is carriedout boundwithbeta lipoproteins (VLDL). Absorption, Transportation and Storage
- 11. Two classes of compounds, phylloquinone (K1) and menaquinones (K2), are primarily responsible for vitamin K activity. vitamin K is transformed from the hydroquinone form (KH2) to the epoxide form (KO), releasing the amount of energy required to generate the carboxylation reaction Metabolism
- 12. Recommended Dietary Allowance (RDA) for Iron Age Males (mg/day) Females (mg/day) 0-6 months 0.27 0.27 7-12 months 11 11 1-3 years 7 7 4-8 years 10 10 9-13 years 8 8 14-18 years 11 15 19-50 years 8 18 51 years and older 8 8 All ages 27 27
- 13. Bruising from bleeding into the skin. Nosebleeds. Bleeding gums. Bleeding in stomach. Blood in urine. Blood in stool. Tarry black stool. Extremely heavy menstrual bleeding. Symptoms of Vitamin K Deficiency
- 14. Reference:- 1. https://www.dictionary.com/browse/vitamin.https://en.m.wikipedia.org/wiki/vitamin. https://www.medicalnewstoday.com/articles/219867 https://https//fullscript.com/blog/vitamin-k/fullscript.com/blog/vitamin-k 2. Book Biochemistry: Third Edition David Hames & Nigel Hooper.