This study assessed the prevalence and predictors of mental health problems among 1,855 farmworkers in Southeastern Anatolia, Turkey. The overall prevalence of mental health problems was 31.5%, with women (35%) reporting higher rates than men (28.2%). Logistic regression analyses identified several significant predictors of mental health problems for both men and women, including poor general health, chronic diseases, traumatic life events, and economic hardship. Additional gender-specific predictors included factors like settlement type, disability of a child, and lack of access to a family physician for women, as well as seasonal work patterns and pesticide exposure for men. The findings highlight the need for improved mental health services and an integrated approach to healthcare for this population.