The Renaissance began in Italy in the late Middle Ages and spread to Europe by the 16th century. It had a profound impact on European intellectual and artistic life, influencing fields like art, philosophy, literature, and science. Key developments included the emergence of humanism as a new philosophy focusing on Greek and Roman sources, breakthroughs in science like Copernicus' theory challenging the Ptolemaic system, and influential artists like Leonardo da Vinci and Michelangelo producing famous works that epitomized Renaissance ideals. The movement also spread to other regions like France, Germany, England, and Spain in the 15th-16th centuries, influencing their cultures as well through art, literature, architecture, and other areas.