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Self-­‐testing	
  for	
  HIV:	
  
initial	
  experience	
  of	
  the	
  
UK’s	
  first	
  kit
Dr	
  Michael	
  Brady
Medical	
  Director,	
  Terrence	
  Higgins	
  Trust
Consultant	
  in	
  Sexual	
  Health	
  &	
  HIV,	
  Kings	
  College	
  Hospital
Context
— HIV	
  testing	
  rates	
  in	
  the	
  UK	
  remain	
  unacceptably	
  low
— 17%	
  of	
  those	
  living	
  with	
  HIV	
  remain	
  undiagnosed1
— Mathematical	
  modelling	
  data	
  (MSM)	
  show:
— Increasing	
  testing	
  rates	
  would	
  reduce	
  HIV	
  incidence2
— HIV	
  testing	
  (with	
  other	
  prevention	
  strategies)	
  could	
  nearly	
  half	
  
the	
  expected	
  infections	
  between	
  now	
  and	
  20203
— There	
  are	
  well	
  recognised	
  barriers	
  to	
  testing	
  and	
  services	
  do	
  
not	
  have	
  capacity	
  to	
  manage	
  increased	
  volumes	
  of	
  testing
— HIV	
  self	
  testing	
  may	
  address	
  these	
  issues
1
HIV	
  in	
  the	
  United	
  Kingdom.	
  2015	
  report.	
  PHE
2
Philips	
  A	
  et	
  al	
  Potential	
  impact	
  on	
  HIV	
  incidence	
  of	
  higher	
  HIV	
  testing	
  rates	
  and	
  earlier	
  antiretroviral	
  therapy	
  initiation	
  in	
  MSM.	
  2015	
  Sep	
  
10;29(14):1855-­‐62
3
Punyacharoensin	
  et	
  al (2016)	
  Effect	
  of	
  pre-­‐exposure	
  prophylaxis	
  and	
  combination	
  HIV	
  prevention	
  for	
  men	
  who	
  have	
  sex	
  with	
  men	
  in	
  the	
  UK:	
  a	
  
mathematical	
  modelling	
  study.	
  Lancet	
  Online	
  January	
  13	
  2016
HIV	
  self	
  testing
— Legalised	
  in	
  the	
  UK	
  in	
  April	
  2014
— Biosure	
  HIV	
  self-­‐testing	
  kit	
  licensed	
  in	
  April	
  2015
— Finger-­‐prick	
  2nd generation	
  blood	
  test	
  (2.5µl)
— Result	
  read	
  in	
  15	
  minutes
— Post	
  Marketing	
  Surveillance	
  data	
  
— April	
  2015	
  – February	
  2016
Disclosure:	
  I	
  have	
  no	
  financial	
  relationship	
  with	
  
Biosure
HIV self-testing
— Available to buy on-line (£29.95)
— Post marketing surveillance:
— Number and timing of orders
— Gender of client
— Postcode of residence
— User feedback:
— E-mail and telephone feedback
— User surveys
— http://www.peblfeedback.com/hivselftest
Results
— 27,917 units sold between April ‘15 – February ‘16
— 10.5% have ordered a test more than once
— 50.4% (1644/3259) had never tested before
April 2015 – February 2016
Gender
Male 76.6%
Female 23.4%
Geographical location
‘Non-metropolitan’ 21,027 (75.3%)
London 4,841 (17.3%)
Manchester 879 (3.2%)
Birmingham 492 (1.8%)
Leeds 360 (1.3%)
Liverpool 318 (1.1%)
HIV self-test: order history
Similar	
  pattern	
  of	
  testing	
  behaviour	
  seen	
  in	
  home	
  sampling	
  services1
1Brady	
  et	
  al	
  Home	
  HIV	
  sampling	
  linked	
  to	
  national	
  HIV	
  testing	
  campaigns:	
  a	
  novel	
  approach	
  to	
  improve	
  
HIV	
  diagnosis.	
  Third	
  joint	
  conference	
  of	
  BHIVA	
  and	
  BASHH.	
  April	
  2014	
  (O21)
HIV self-test: kit performance
— Issues of kit performance rely on self-reporting
— Currently no standardised way of recording and
confirming access to care
— 6 reported false reactives (0.02%)
— Expected to be in the range of 53 to 56.
— 12 reported invalid tests (0.04%)
— Device problems, failure to generate a control line
HIV self test: user feedback
— 1334 (4.7%) provided
some kind of feedback
— From a sample of 555
— 97.5% would use it
again
— 98.1% said the test was
easy to do
— 99.4% said it was easy
to read
HIV self test: user feedback (101)
“Simple”
“Easy”
“Convenient”
“Clear
instructions”“Discrete”
“Value for
money”
“Privacy”
“Nearest
clinic too far
away“
“Excellent”
“Amazing”
“Horrendous”
http://www.peblfeedback.com/hivs
elftest
“Waiting for
result from
clinic is
stressful“
Conclusions (1)
— HIV self testing is proving popular in a ‘private’
setting
— Lower than expected levels of kit failure or false
positives
— User feedback very positive
— Ordering closely linked to social media promotion
and ‘HIV’ in the news
Conclusions (2)
— Post marketing surveillance gives only a limited picture
— Ideal to integrate data collection with statutory returns
— More data are needed on:
— How the test would perform if available for free
— How the test will perform when targeted at those most at
risk
— The experience of receiving a reactive result
— How to ensure and confirm access to care
— Impact on testing rates and sexual behaviour
Acknowledgements
Biosure UK Ltd
— Gary Carpenter
— Brigette Bard
michaelbrady@nhs.net

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Self-testing for HIV: initial experience of the UK’s first kit

  • 1. Self-­‐testing  for  HIV:   initial  experience  of  the   UK’s  first  kit Dr  Michael  Brady Medical  Director,  Terrence  Higgins  Trust Consultant  in  Sexual  Health  &  HIV,  Kings  College  Hospital
  • 2. Context — HIV  testing  rates  in  the  UK  remain  unacceptably  low — 17%  of  those  living  with  HIV  remain  undiagnosed1 — Mathematical  modelling  data  (MSM)  show: — Increasing  testing  rates  would  reduce  HIV  incidence2 — HIV  testing  (with  other  prevention  strategies)  could  nearly  half   the  expected  infections  between  now  and  20203 — There  are  well  recognised  barriers  to  testing  and  services  do   not  have  capacity  to  manage  increased  volumes  of  testing — HIV  self  testing  may  address  these  issues 1 HIV  in  the  United  Kingdom.  2015  report.  PHE 2 Philips  A  et  al  Potential  impact  on  HIV  incidence  of  higher  HIV  testing  rates  and  earlier  antiretroviral  therapy  initiation  in  MSM.  2015  Sep   10;29(14):1855-­‐62 3 Punyacharoensin  et  al (2016)  Effect  of  pre-­‐exposure  prophylaxis  and  combination  HIV  prevention  for  men  who  have  sex  with  men  in  the  UK:  a   mathematical  modelling  study.  Lancet  Online  January  13  2016
  • 3. HIV  self  testing — Legalised  in  the  UK  in  April  2014 — Biosure  HIV  self-­‐testing  kit  licensed  in  April  2015 — Finger-­‐prick  2nd generation  blood  test  (2.5µl) — Result  read  in  15  minutes — Post  Marketing  Surveillance  data   — April  2015  – February  2016 Disclosure:  I  have  no  financial  relationship  with   Biosure
  • 4. HIV self-testing — Available to buy on-line (£29.95) — Post marketing surveillance: — Number and timing of orders — Gender of client — Postcode of residence — User feedback: — E-mail and telephone feedback — User surveys — http://www.peblfeedback.com/hivselftest
  • 5. Results — 27,917 units sold between April ‘15 – February ‘16 — 10.5% have ordered a test more than once — 50.4% (1644/3259) had never tested before April 2015 – February 2016 Gender Male 76.6% Female 23.4% Geographical location ‘Non-metropolitan’ 21,027 (75.3%) London 4,841 (17.3%) Manchester 879 (3.2%) Birmingham 492 (1.8%) Leeds 360 (1.3%) Liverpool 318 (1.1%)
  • 6. HIV self-test: order history Similar  pattern  of  testing  behaviour  seen  in  home  sampling  services1 1Brady  et  al  Home  HIV  sampling  linked  to  national  HIV  testing  campaigns:  a  novel  approach  to  improve   HIV  diagnosis.  Third  joint  conference  of  BHIVA  and  BASHH.  April  2014  (O21)
  • 7. HIV self-test: kit performance — Issues of kit performance rely on self-reporting — Currently no standardised way of recording and confirming access to care — 6 reported false reactives (0.02%) — Expected to be in the range of 53 to 56. — 12 reported invalid tests (0.04%) — Device problems, failure to generate a control line
  • 8. HIV self test: user feedback — 1334 (4.7%) provided some kind of feedback — From a sample of 555 — 97.5% would use it again — 98.1% said the test was easy to do — 99.4% said it was easy to read
  • 9. HIV self test: user feedback (101) “Simple” “Easy” “Convenient” “Clear instructions”“Discrete” “Value for money” “Privacy” “Nearest clinic too far away“ “Excellent” “Amazing” “Horrendous” http://www.peblfeedback.com/hivs elftest “Waiting for result from clinic is stressful“
  • 10. Conclusions (1) — HIV self testing is proving popular in a ‘private’ setting — Lower than expected levels of kit failure or false positives — User feedback very positive — Ordering closely linked to social media promotion and ‘HIV’ in the news
  • 11. Conclusions (2) — Post marketing surveillance gives only a limited picture — Ideal to integrate data collection with statutory returns — More data are needed on: — How the test would perform if available for free — How the test will perform when targeted at those most at risk — The experience of receiving a reactive result — How to ensure and confirm access to care — Impact on testing rates and sexual behaviour
  • 12. Acknowledgements Biosure UK Ltd — Gary Carpenter — Brigette Bard [email protected]