Toxicity Studies of Aqueous-Methanol Extract of Dennettia tripetala (Pepper fruit) Fresh Ripe Fruits in Experimental Rats

1) The study evaluated the toxicity of an aqueous-methanol extract of Dennettia tripetala fresh ripe fruits in rats over 14 days. 2) The extract showed no significant effects on liver and kidney function at 100 mg/kg body weight but caused toxicity at higher doses based on changes in biochemical parameters and antioxidant levels. 3) The extract significantly decreased levels of antioxidant enzymes like SOD, GSH, GPx and GST at doses of 200 and 400 mg/kg, indicating potential oxidative stress, while MDA and CAT were not significantly affected.