The Typesafe Stack includes Scala, Akka, and Play frameworks for building scalable applications. Scala is a statically typed, functional programming language that runs on the JVM and interoperates with Java. Akka is an event-driven middleware for building distributed, fault-tolerant applications using actors. Play is a web framework that enables fast development of RESTful APIs and web applications using Scala templates. Together, these frameworks provide tools for building scalable, distributed systems with easy development.