Virtualizing Active Directory domain controllers can provide benefits like increased availability and scalability. However, there are some safety considerations to take into account, such as preventing "USN rollback" which occurs when a domain controller's state is reverted, like after restoring from a snapshot. New features in Windows Server 2012 and VMware vSphere help address this, such as the VM Generation ID which changes when the domain controller state is modified, triggering safety mechanisms to isolate changes. Proper configuration following best practices is important for successfully virtualizing Active Directory.