vedanshu malviya

innovative drug delivery system enzyme immobilization sustained release drug delivery system equivalent conductivity pharmacovigilance healthcare novel drug delivery system bioavailability polymers hepatic first pass metabolism conductometer compression cracking u.s. department of health and human services food and drug administration parent guideline: pharmaceutical development annex to the parent guideline: pharmaceutical deve addition of annex to the parent guideline punches granules mixing capping coating/ pelletization tangential spray bottom spray top spray granulation fluidizing bed processing chikitsa dravyaguna vigyan ayurvedic pharmacology samhitas ayurveda half-life (t) clearance protein binding volume of distribution (vd) pharmacology excetion metabolism distribution absorption randomized mixing idela mixing machines drug product example of drug release crdds approaches in formulation of crdds classification control drug delivery system effect of dilution molecular conductance specific conductance specific resistance conductance ohms law conductivity cell dosage form without the use of water alternate to tablets ndds oral dispersible strips oral dispersible film gastro retentive drug delivery system grdds drug substance colloidal dispersions classification of colloids types of colloids emulsion extraction solvents distillation solutions medicina medical medicine reactions analysis chemistry methods to entrap enzymes enzyme study microspheres tablet novel drug delivery transdermal drug delivery transdermal patches local therapeutic effects intramuscular tissue rate-controlling sustained drug delivery grafted implants covalently immobilized enzyme bound immobilized enzymes entrapped immobilized enzymes immobilization applications human organism holistic concept psychosocial concept ecological concept biomedical concept polymerization coating materials microencapsulation pressurized mdi dry powder inhalers (dpis) metered nasal spray pumps bypass hepatic metabolism systemic circulation brain targetting lungs tragetting pulmonary drug delivery system nasal drug delivery increase bioavailability epidermis skin drug delivery formulation approaches basic components of tdds tdds human skin skin permeability drug release from skin drug delivery by skin skin permeation uppsala monitoring centre monitor drug safety reporting adverse reaction in vivo distribution pharmaceutical technology systemic therapeutic activity patient-drug pharmacokinetics kinetic profile of drugs adjustment of dosing regimen pharmacolinetic characterizati bioequivalence physiological function of drug knowledge of drug action clinical medicine pharmacokinetic biopharmaceutic physicians charaka samhita adverse reactions nccam penetration enhancers controlled release microcapsules drug delivery systems dry coating press coating enteric coating sugar coating compression coating oral solid dosage forms functional advances troubleshooting film coating formulation ingredients direct compression dry granulation wet granulation post-approval phase clinical trials morbidity and mortality